Bioactive Sheath/Core Nanofibers Containing Olive Leaf Extract

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dc.contributor.authorDogan, Gamze
dc.contributor.authorBasal, Guldemet
dc.contributor.authorBayraktar, Oguz
dc.contributor.authorOzyildiz, Figen
dc.contributor.authorUzel, Atac
dc.contributor.authorErdogan, Ipek
dc.date.accessioned2019-10-27T22:58:25Z
dc.date.available2019-10-27T22:58:25Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study aimed at producing silk fibroin (SF)/hyaluronic acid (HA) and olive leaf extract (OLE) nanofibers with sheath/core morphology by coaxial electrospinning method, determining their antimicrobial properties, and examining release profiles of OLE from these coaxial nanofibers. Optimum electrospinning process and solution parameters were determined to obtain uniform and bead-free coaxial nanofibers. Scanning electron microscopy and transmission electron microscopy (TEM) were used to characterize the morphology of the nanofibers. The antimicrobial activities of nanofibers were tested according to AATCC test method 100. Total phenolic content and total antioxidant activity were tested using in vitro batch release system. The quality and quantity of released components of OLE were determined by high-performance liquid chromatography. The changes in nanofibers were examined by Fourier-transform infrared spectroscopy. Uniform and bead-free nanofibers were produced successfully. TEM images confirmed the coaxial structure. OLE-loaded nanofibers demonstrated almost perfect antibacterial activities against both of gram-negative and gram-positive bacteria. Antifungal activity against C. albicans was rather poor. After a release period of 1 month, it was observed that similar to 70-95% of the OLE was released from nanofibers and it was still bioactive. Overall results indicate that the resultant shell/core nanofibers have a great potential to be used as biomaterials. (C) 2015 Wiley Periodicals, Inc.en_US
dc.description.sponsorshipDUAG Natural Productsen_US
dc.description.sponsorshipThe authors gratefully acknowledge the DUAG Natural Products for their support.en_US
dc.identifier.doi10.1002/jemt.22603en_US
dc.identifier.endpage49en_US
dc.identifier.issn1059-910X
dc.identifier.issn1097-0029
dc.identifier.issue1en_US
dc.identifier.pmid26626545en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.1002/jemt.22603
dc.identifier.urihttps://hdl.handle.net/11454/51543
dc.identifier.volume79en_US
dc.identifier.wosWOS:000369165100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofMicroscopy Research and Techniqueen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcoaxial electrospinningen_US
dc.subjectactive agent release profileen_US
dc.subjectantimicrobial activityen_US
dc.subjectantioxidant activityen_US
dc.titleBioactive Sheath/Core Nanofibers Containing Olive Leaf Extracten_US
dc.typeArticleen_US

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