Evaluation of (99m)Technetium-Vancomycin Imaging Potential in Experimental Rat Model for the Diagnosis of Infective Endocarditis

Basit Öğe Kaydı
dc.authoridYILMAZ, Osman/0000-0001-7817-7576
dc.authoridKış, Mehmet/0000-0003-0775-8992
dc.authoridAcar, Emine/0000-0002-6861-8814
dc.authoridDiniz, Gulden/0000-0003-1512-7584
dc.authoridBekis, Recep/0000-0002-8313-8974
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authoridTatli Kis, Tuba/0000-0001-6952-3748
dc.authorscopusid57226625769
dc.authorscopusid24401322500
dc.authorscopusid7103213364
dc.authorscopusid57202717071
dc.authorscopusid6602719646
dc.authorscopusid57191053922
dc.authorscopusid6602540539
dc.authorwosidYILMAZ, Osman/V-3632-2019
dc.authorwosidKış, Mehmet/AAE-3815-2021
dc.authorwosidBekis, Recep/P-8094-2014
dc.contributor.authorKis, Tuba Tatli
dc.contributor.authorKose, Sukran
dc.contributor.authorYilmaz, Osman
dc.contributor.authorKis, Mehmet
dc.contributor.authorYurt, Fatma
dc.contributor.authorAcar, Emine
dc.contributor.authorBekis, Recep
dc.date.accessioned2023-01-12T20:11:41Z
dc.date.available2023-01-12T20:11:41Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground: Infective endocarditis (IE) is an infection of the heart's endocardial surface. In recent years, nuclear imaging methods have gained importance in the diagnosis of IE. The present study aims to investigate the imaging potential of Tc-99m-labeled vancomycin (Tc-99m-Van-comycin) as a new agent that would enable the diagnosis of IE in its early stages when it is difficult to diagnose or has small vegetation in the experimental rat model. Methods: Tc-99m-Vancomycin scintigraphy was evaluated for its accumulation in IE with Staphylococcus aureus performed in an experimental rat model. Serial planar scintigraphic and biodistribution analysis of infected vegetations are compared to rats with sterile vegetations. The heart was identified as an infected organ, the liver was identified as a non-infected organ and the heart/liver uptake ratio (T / NT ratio) was compared between infective endocarditis and sterile endocarditis groups. Results: Planar scintigrams (in vivo measurements) showed more uptake in the heart of rats in the infective endocarditis group compared to the uptake in the heart of rats in the sterile endocarditis group, but this difference was not statistically significant (p>0.05). From the ex vivo measurements, the Tc-99m-Vancomycin heart uptake increased significantly (p = 0.016), liver uptake was significantly decreased (p = 0.045) and the T/NT ratio was significantly higher (p = 0.014) in the infective endocarditis group compared to the sterile endocarditis group. Conclusion: In this experimental study, Tc-99m-Vancomycin scintigraphy ensured the detection of ex vivo infected tissue in a rat model of IE. In addition, the absence of significant Tc-99m-Van-comycin uptake in the sterile endocarditis group indicates that this agent targeted the infected tissue instead of the sterile inflammatory tissue. Finally, this agent should also be evaluated with animal-specific imaging devices.en_US
dc.identifier.doi10.2174/1573405616666201229161850
dc.identifier.endpage789en_US
dc.identifier.issn1573-4056
dc.identifier.issn1875-6603
dc.identifier.issue6en_US
dc.identifier.pmid33372880en_US
dc.identifier.scopus2-s2.0-85112124835en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage781en_US
dc.identifier.urihttps://doi.org/10.2174/1573405616666201229161850
dc.identifier.urihttps://hdl.handle.net/11454/78170
dc.identifier.volume17en_US
dc.identifier.wosWOS:000669919000012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Medical Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInfective endocarditisen_US
dc.subjecttechnetium-99men_US
dc.subjectvancomycinen_US
dc.subjectT/Nt ratioen_US
dc.subjectscintigraphyen_US
dc.subjectimagingen_US
dc.subjectScintigraphyen_US
dc.subjectBiodistributionen_US
dc.subjectVancomycinen_US
dc.subjectConferen_US
dc.subjectAgenten_US
dc.titleEvaluation of (99m)Technetium-Vancomycin Imaging Potential in Experimental Rat Model for the Diagnosis of Infective Endocarditisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu