Antiepileptic drug-induced osteopenia in ambulatory epileptic children receiving a standard vitamin D3 supplement

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dc.contributor.authorTekgul H.
dc.contributor.authorDizdarer G.
dc.contributor.authorDemir N.
dc.contributor.authorOzturk C.
dc.contributor.authorTutuncuoglu S.
dc.date.accessioned2019-10-27T00:11:27Z
dc.date.available2019-10-27T00:11:27Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractDual energy X-ray absorptiometry (DEXA) is a non-invasive, rapid, accurate and highly reproducible method for the assessment of antiepileptic drug (AED)-induced osteopenia in epileptic children. In this study, we investigated bone mineral density (BMD) using DEXA in 56 epileptic children receiving long-term AED treatment for at least 2 years. All children received AED monotherapy or polytherapy plus a standard vitamin D3 supplement (400 U/day). BMD measurements were made from lumbar spine (L2-L4) regions. Age- and sex-specific BMD SD scores were calculated for each child. Osteopenia was defined as SD scores less than -1.5. There was no significant difference in mean BMD values between epileptic children receiving monotherapy or polytherapy. The results were also compared to the age- and sex-specific BMD SD scores obtained from healthy Turkish children. Only three patients (5%) receiving AED therapy had a BMD SD score less than -1.5. This rate is relatively lower than the rates of previous studies conducted on ambulatory children on long-term AED treatment without vitamin D3 supplementation. © Freund Publishing House Ltd., London.en_US
dc.identifier.doi10.1515/JPEM.2005.18.6.585en_US
dc.identifier.endpage588en_US
dc.identifier.issn0334-018X
dc.identifier.issue6en_US
dc.identifier.pmid16042326en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage585en_US
dc.identifier.urihttps://doi.org/10.1515/JPEM.2005.18.6.585
dc.identifier.urihttps://hdl.handle.net/11454/22178
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFreund Publishing House Ltden_US
dc.relation.ispartofJournal of Pediatric Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiepileptic drugen_US
dc.subjectBone mineral densityen_US
dc.subjectEpilepsyen_US
dc.subjectOsteopeniaen_US
dc.subjectVitamin Den_US
dc.titleAntiepileptic drug-induced osteopenia in ambulatory epileptic children receiving a standard vitamin D3 supplementen_US
dc.typeArticleen_US

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