Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy

Basit Öğe Kaydı
dc.contributor.authorAltay, Canan
dc.contributor.authorSecil, Mustafa
dc.contributor.authorDemir, Tevfik
dc.contributor.authorAtik, Tahir
dc.contributor.authorAkinci, Gulcin
dc.contributor.authorKutbay, Nilufer Ozdemir
dc.contributor.authorTemeloglu, Ela Keskin
dc.contributor.authorSimsir, Ilgin Yildirim
dc.contributor.authorOzisik, Secil
dc.contributor.authorDemir, Leyla
dc.contributor.authorEren, Erdal
dc.contributor.authorTuna, Emine Burcin
dc.contributor.authorAytac, Hasibe
dc.contributor.authorOnay, Huseyin
dc.contributor.authorAkinci, Baris
dc.date.accessioned2019-10-27T10:48:27Z
dc.date.available2019-10-27T10:48:27Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractPURPOSE We aimed to investigate residual adipose tissue with whole-body magnetic resonance imaging to differentiate between subtypes of lipodystrophy. METHODS A total of 32 patients 12 with congenital generalized lipodystrophy [CGL], 1 with acquired generalized lipodystrophy [AGL], 12 with familial partial lipodystrophy [FPLD], and 7 with acquired partial lipodystrophy [APL]) were included. RESULTS Despite generalized loss of metabolically active adipose tissue, patients with CGL1 caused by AGPAT2 mutations had a significant amount of residual adipose tissue in the scalp, earlobes, retro-orbital region, and palms and soles. No residual adipose tissue was noted particularly in the head and neck, palms and soles in CGL2 caused by BSCL2 mutations. CGL4 caused by mutations in the PTRF gene was characterized with well-preserved retro-orbital and bone marrow fat in the absence of any visible residual adipose tissue in other areas. No residual adipose tissue was observed in AGL. Despite loss of subcutaneous fat, periarticular adipose tissue was preserved in the lower limbs of patients with FPLD. Retro-orbital adipose tissue was surprisingly preserved in APL, although they lacked head and neck fat. CONCLUSION Lipodystrophies are a heterogeneous group of disorders characterized by generalized or partial loss of adipose tissue, which can be congenital or acquired. Our results suggest that residual adipose tissue characteristics can help distinguish different subtypes of lipodystrophy.en_US
dc.identifier.doi10.5152/dir.2017.17019en_US
dc.identifier.endpage434en_US
dc.identifier.issn1305-3612
dc.identifier.issue6en_US
dc.identifier.pmid29044029en_US
dc.identifier.startpage428en_US
dc.identifier.urihttps://doi.org/10.5152/dir.2017.17019
dc.identifier.urihttps://hdl.handle.net/11454/31538
dc.identifier.volume23en_US
dc.identifier.wosWOS:000414273500004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofDiagnostic and Interventional Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleDetermining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu