The İmportance of tumor markers in patients undergoing resection for lung metastasis of colorectal carcinoma
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: In patients with suitable conditions, complete resection is a potential curative treatment for lung metastases of colorectal cancers (CRC). Various prognostic factors affecting survival have been reported in these patients. In our study, the prognostic significance of CEA and CA19-9 tumor markers in patients who underwent lung resection for CRC metastasis was researched. Methods: Fifty-three patients who underwent lung resection for CRC metastasis between January 2015 and July 2021 were included in the study. The relationship between preoperative and postoperative CEA and CA19-9 values, survival times, tumor size, and preoperative CEA and CA19-9 levels were investigated. Results: Patients with high preoperative and postoperative CEA had shorter survival (OS) compared with patients with lower values (p ? 0.001 and p = 0.009, respectively). Disease-free survival (DFS) was also shorter in patients with higher preoperative CEA values (p = 0.008). For patients with higher preoperative and postoperative CA 19–9 values, OS and DFS were shorter (p = 0.013 and p ? 0.001) and (p = 0.042 and p ? 0.001), respectively. There was a weak positive correlation between preoperative CEA value and tumor size (p = 0.008, Pearson correlation coefficient = 0.360). However, a strong positive correlation between preoperative CA19-9 value and tumor size was discovered (p ? 0.001, Pearson correlation coefficient = 0.603). Conclusion: In our study, it was shown that preoperative-postoperative CEA and CA19-9 levels in patients with metastatic colon carcinoma are associated with overall survival. © 2023 The Authors. The Clinical Respiratory Journal published by John Wiley & Sons Ltd.
Açıklama
Anahtar Kelimeler
CA 19-9 value, colorectal carcinoma, lung metastases, pulmonary metastasectomy
Kaynak
Clinical Respiratory Journal
WoS Q Değeri
Scopus Q Değeri
Q3
