Bioevaluation of 99mTc(CO) 3-Guanine in vitro and in vivo
| dc.contributor.author | Içhedef C. | |
| dc.contributor.author | Şenocak K. | |
| dc.contributor.author | Ertay T. | |
| dc.contributor.author | Teksöz S. | |
| dc.contributor.author | Medine E.I. | |
| dc.contributor.author | Bekiş R. | |
| dc.contributor.author | Ünak P. | |
| dc.date.accessioned | 2019-10-26T21:50:50Z | |
| dc.date.available | 2019-10-26T21:50:50Z | |
| dc.date.issued | 2012 | |
| dc.department | Ege Üniversitesi | en_US |
| dc.description.abstract | The aim of this study is to examine biological behaviour of radiolabeled guanine with [Tc(CO) 3] + core in vitro and in vivo. In vitro biological behavior of 99mTc(CO) 3-Gua was evaluated on Lung (A-549), Breast (MCF-7), Colonic (Caco) carcinoma cell lines and normal human bronchial epithelial (NHBE). 99mTc(CO) 3-Gua compound showed high uptake on A-549 cell line when compared to NHBE cell line. Biodistribution characteristics of 99mTc(CO) 3-Gua was evaluated using New Zeland Rabbits. Scintigraphic results showed that a high level of radioactivity was observed in the lungs and liver shortly after administration of the 99mTc(CO) 3-Gua and excretion takes place via both renal and hepatobiliary route. It was concluded that 99mTc(CO) 3-Gua could be used as a nucleotide radiopharmaceutical for imaging purposes. © 2012 Akadémiai Kiadó, Budapest, Hungary. | en_US |
| dc.identifier.doi | 10.1007/s10967-011-1493-0 | |
| dc.identifier.endpage | 743 | en_US |
| dc.identifier.issn | 0236-5731 | |
| dc.identifier.issn | 0236-5731 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.scopusquality | Q2 | en_US |
| dc.identifier.startpage | 739 | en_US |
| dc.identifier.uri | https://doi.org/10.1007/s10967-011-1493-0 | |
| dc.identifier.uri | https://hdl.handle.net/11454/18771 | |
| dc.identifier.volume | 291 | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Journal of Radioanalytical and Nuclear Chemistry | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | 99mTechnetium | en_US |
| dc.subject | Cell culture | en_US |
| dc.subject | Guanine | en_US |
| dc.subject | Imaging | en_US |
| dc.title | Bioevaluation of 99mTc(CO) 3-Guanine in vitro and in vivo | en_US |
| dc.type | Article | en_US |
