Bioevaluation of 99mTc(CO) 3-Guanine in vitro and in vivo
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study is to examine biological behaviour of radiolabeled guanine with [Tc(CO) 3] + core in vitro and in vivo. In vitro biological behavior of 99mTc(CO) 3-Gua was evaluated on Lung (A-549), Breast (MCF-7), Colonic (Caco) carcinoma cell lines and normal human bronchial epithelial (NHBE). 99mTc(CO) 3-Gua compound showed high uptake on A-549 cell line when compared to NHBE cell line. Biodistribution characteristics of 99mTc(CO) 3-Gua was evaluated using New Zeland Rabbits. Scintigraphic results showed that a high level of radioactivity was observed in the lungs and liver shortly after administration of the 99mTc(CO) 3-Gua and excretion takes place via both renal and hepatobiliary route. It was concluded that 99mTc(CO) 3-Gua could be used as a nucleotide radiopharmaceutical for imaging purposes. © 2012 Akadémiai Kiadó, Budapest, Hungary.
Açıklama
Anahtar Kelimeler
99mTechnetium, Cell culture, Guanine, Imaging
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
291
Sayı
2
