Intravascular Large B-Cell Lymphoma Diagnosed on Prostate Biopsy: A Case Report

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dc.contributor.authorOzsan, Nazan
dc.contributor.authorSarsik, Banu
dc.contributor.authorYilmaz, Asu Fergun
dc.contributor.authorSimsir, Adnan
dc.contributor.authorDonmez, Ayhan
dc.date.accessioned2019-10-27T22:12:24Z
dc.date.available2019-10-27T22:12:24Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractIntravascular large B-cell lymphoma (IVLBCL) is a very rare type of non-Hodgkin lymphoma, usually affecting elderly patients and characterized by selective infiltration of neoplastic cells within blood vessels' lumina. IVLBCL diagnosed with prostatic involvement is extremely rare. We report a patient of 65 years old, having mostly neurological complaints but diagnosed with IVLBCL upon histopathological examination of transurethral prostate resection material, which revealed large neoplastic cell infiltration totally limited within the lumens of small vessels. By immunohistochemistry, neoplastic cell infiltration was positive with MUM!, bcl-6, and bcl-2 and negative with ALK1, CD10, and CD30, with a high Ki-67 proliferation index. CD34 and CD31 staining showed expression in endothelial cells, highlighting the intravascular nature of neoplastic infiltrate. The patient unfortunately refused to receive treatment and died of the disease 8 months after the diagnosis. IVLBCL, though very rare, should be considered in differential diagnosis of all organ biopsies with intravascular infiltration. Further improvements in the understanding of the pathogenesis and biology of this rare type of lymphoma are mandatory.en_US
dc.identifier.doi10.4274/tjh.2013.0090en_US
dc.identifier.endpage407en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue4en_US
dc.identifier.pmid25541658en_US
dc.identifier.startpage403en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.2013.0090
dc.identifier.urihttps://hdl.handle.net/11454/49413
dc.identifier.volume31en_US
dc.identifier.wosWOS:000348688800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-Hodgkin lymphomaen_US
dc.subjectIntravascular large B-cell lymphomaen_US
dc.subjectProstateen_US
dc.subjectNon-germinal center B-cellen_US
dc.titleIntravascular Large B-Cell Lymphoma Diagnosed on Prostate Biopsy: A Case Reporten_US
dc.typeArticleen_US

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