Therapeutic plasma exchange in hypertriglyceridemic patients

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dc.contributor.authorŞimşir, Ilgın Yıldırım
dc.contributor.authorSoyaltın, Utku Erdem
dc.contributor.authorYürekli, Banu Pınar Şarer
dc.contributor.authorErdoğan, Mehmet
dc.contributor.authorÇetinkalp, Şevki
dc.contributor.authorSaygılı, Füsun
dc.contributor.authorÖzgen, Ahmet Gökhan
dc.date.accessioned2020-12-01T12:36:46Z
dc.date.available2020-12-01T12:36:46Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/aim: High triglyceride (TG) levels are associated with increases in atherosclerotic cardiovascular disease (CVD), hepatic steatosis, and pancreatitis. Acute pancreatitis is a condition with high mortality. Therapeutic plasma exchange (TPE) in the treatment of hypertriglyceridemic pancreatitis (HTGP) is a rapid and effective treatment modality. in this study, the results of TPE were evaluated and the frequency of lipoprotein lipase (LPL) mutation in these patients was determined. Materials and methods: TPE was performed in 31 patients with HTGP at the Adult Therapeutic Apheresis Center. Results: A TG level under 500 mg/dL was achieved by applying apheresis at a median of 2 times (IQR 2–2, min 1, max 6) in the 31 cases. LPL mutation was detected in 8 (25.8%) of the 31 hypertriglyceridemia cases. When TG levels before and after TPE were evaluated, the mean TG level before TPE was significantly higher (3132 ± 1472 mg/dL) than the mean TG level afterwards (948 ± 465 mg/dL, P < 0.001). This result represented a decrease of 69.7% TG after TPE. Conclusion: TPE is a safe, fast, and effective treatment modality in experienced centers.en_US
dc.identifier.doi10.3906/sag-1811-105
dc.identifier.endpage878en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.startpage872en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1811-105
dc.identifier.urihttps://app.trdizin.gov.tr//makale/TXpNMk1qTXdNQT09
dc.identifier.urihttps://hdl.handle.net/11454/67026
dc.identifier.volume49en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleTherapeutic plasma exchange in hypertriglyceridemic patientsen_US
dc.typeArticleen_US

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