Comprehensive Immunohistochemical Analysis of Epithelial-Mesenchymal Transition Biomarkers in the Invasive Micropapillary Cancer of the Breast

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dc.authoridÖz, Özden/0000-0001-5601-1567
dc.authoridKocatepe Cavdar, Demet/0000-0002-3278-3770
dc.contributor.authorOz, Ozden
dc.contributor.authorTasli, Funda Alkan
dc.contributor.authorYuzuguldu, Resmiye Irmak
dc.contributor.authorZengel, Baha
dc.contributor.authorCavdar, Demet Kocatepe
dc.contributor.authorDurak, Merih Guray
dc.contributor.authorDurusoy, Raika
dc.date.accessioned2024-08-31T07:47:21Z
dc.date.available2024-08-31T07:47:21Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Invasive micropapillary carcinoma (IMPC) of the breast is commonly associated with a poor prognosis due to its high incidence of lymphovascular invasion and lymph node metastasis (LNM). Our study is aimed at investigating the prognostic significance of the expressions of E-cadherin (E-cad), N-cadherin (N-cad), CD44s, and beta-catenin (beta-cat). In addition, it is aimed at deciphering the consistency of these markers between the IMPC, the invasive breast carcinoma, no-special type (IBC-NST), and LNM components in the same IMPC cases. Methods: Sixty-two IMPC cases with LNM from 1996 to 2018 were analyzed. Immunohistochemical staining was performed separately on the three regions for each patient. Statistical analyses included Kaplan-Meier, Cox regression, and McNemar's statistical tests. Results: Loss of CD44 expression in IMPC, IBC-NST, and LNM areas was associated with poor prognosis in overall survival (OS) ( p = 0.010 , p < 0.0005 , p = 0.025 ). Loss of CD44 expression in the IBC-NST, gain of N-cad expression in the IMPC, and loss of beta-cat expression in the LNM areas were indicators of poor prognosis in disease-free survival (DFS) (p = 0.005 , p = 0.041 , p = 0.009). Conclusion: Our evaluation of this rare subtype, focusing on the expression of key epithelial-mesenchymal transition (EMT) molecules, revealed that it shares characteristics with the IBC-NST component within mixed tumors. Notably, contrary to expectations, a reduction in CD44 expression was found to adversely affect both OS and DFS. By conducting staining procedures simultaneously across three regions within the same patient, a novel approach has provided valuable insights into the mechanisms of EMT.en_US
dc.identifier.doi10.1155/2024/2350073
dc.identifier.issn2090-3170
dc.identifier.issn2090-3189
dc.identifier.pmid38903413en_US
dc.identifier.scopus2-s2.0-85199206836en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1155/2024/2350073
dc.identifier.urihttps://hdl.handle.net/11454/104400
dc.identifier.volume2024en_US
dc.identifier.wosWOS:001262709100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofInternational Journal of Breast Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectBiomarkeren_US
dc.subjectEpithelial-Mesenchymal Transition (Emt)en_US
dc.subjectMetastasisen_US
dc.subjectMicropapillary Breast Carcinomaen_US
dc.subjectPrognosisen_US
dc.titleComprehensive Immunohistochemical Analysis of Epithelial-Mesenchymal Transition Biomarkers in the Invasive Micropapillary Cancer of the Breasten_US
dc.typeArticleen_US

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