Cytokine gene polymorphism and early graft rejection in liver transplant recipients

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dc.contributor.authorKarasu Z.
dc.contributor.authorUlukaya S.
dc.contributor.authorAyanoglu H.O.
dc.contributor.authorBasturk B.
dc.contributor.authorUlukaya E.
dc.contributor.authorAkyildiz M.
dc.contributor.authorTokat Y.
dc.date.accessioned2019-10-27T00:13:04Z
dc.date.available2019-10-27T00:13:04Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractCytokines, which play important roles in allograft rejection, show variable production among individuals. These variations may be related to genetic polymorphisms within the regulatory regions of the cytokine genes. We investigated the association between the role tumor necrosis factor alpha (TNF-?), transforming growth factor-beta (TGF-ß), interferon gamma (IFN-?), interleukin (IL)-10 and IL-6 gene polymorphisms and early graft rejection among liver transplant recipients. Forty-three liver transplant recipients enrolled in this study were divided into 2 groups based on events in the first 2 months posttransplantations, namely, those experiencing at least 1 rejection episode (n = 26) or those without any episode (n = 17). The allele or genotype frequencies of cytokine gene polymorphisms showed no difference between liver recipients with or without nonrejection. In conclusion, there was no significant correlation between early graft rejection and cytokine gene polymorphism of TNF-?, TGF-ß, IL-10, IL-6, and IFN-? in liver transplant recipients.en_US
dc.identifier.doi10.1016/j.transproceed.2004.10.034en_US
dc.identifier.endpage2795en_US
dc.identifier.issn0041-1345
dc.identifier.issue9en_US
dc.identifier.pmid15621151en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2791en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2004.10.034
dc.identifier.urihttps://hdl.handle.net/11454/22419
dc.identifier.volume36en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleCytokine gene polymorphism and early graft rejection in liver transplant recipientsen_US
dc.typeArticleen_US

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