Disease burden, clinical management and unmet treatment need of patients with moderate to severe alopecia areata; consensus statements, insights, and practices from CERTAAE (Central/Eastern EU, Russia, Türkiye AA experts) Delphi panel

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dc.authoridTrzeciak, Magdalena/0000-0002-8206-8441
dc.authoridRudnicka, Lidia/0000-0002-8308-1023
dc.authoridOnsun, Nahide/0000-0001-6259-0219
dc.contributor.authorRudnicka, Lidia
dc.contributor.authorTrzeciak, Magdalena
dc.contributor.authorAlpsoy, Erkan
dc.contributor.authorArenberger, Petr
dc.contributor.authorAlper, Sibel
dc.contributor.authorBenakova, Nina
dc.contributor.authorBobko, Svetlana
dc.date.accessioned2024-08-31T07:46:56Z
dc.date.available2024-08-31T07:46:56Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives This study aims to update the understanding of Alopecia Areata (AA) in Poland, Czechia, Russia, and T & uuml;rkiye, focusing on the disease burden, clinical management, and patient journey. It seeks to establish a consensus on optimal management strategies for AA in these regions.Methods A modified 2-round Delphi panel was conveyed with 23 Dermatologists (Russia; 4, T & uuml;rkiye; 7, Poland; 6, and Czechia; 6). The Delphi questionnaire consisted of 61 statements and 43 questions designed to obtain an overall understanding of the perception and acceptance of available information regarding the care of patients with alopecia areata.Results The study revealed that moderate-to-severe AA significantly impacts patients' and their families' QoL, consistent with previous studies. AA was found to cause more substantial impairment when additional lesions appeared in visible areas besides the scalp. Work and productivity impairment were notably higher in adults with moderate-to-severe AA. Diagnostic consensus highlighted the importance of skin biopsies and trichoscopy, while the need for more practical severity scoring systems was emphasized. Current treatments, including topical therapies, corticosteroids, and systemic immune modifiers, were deemed insufficient, highlighting the unmet medical need.Conclusion The Delphi study underscores a significant disease burden and unmet medical needs in patients with moderate-to-severe AA. It highlights the necessity of access to novel treatments and further research to develop more effective therapies with a tolerable safety profile. The findings align with global research, emphasizing the psychosocial impact of AA and the need for standardized, effective treatment protocols.en_US
dc.description.sponsorshipPfizeren_US
dc.description.sponsorshipThe author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was funded by Pfizer. Project management and technical support was provided by Remedium Consulting Group and funded by Pfizer. Pfizer employees did not have any involvement in the achieved consensus nor the decision for journal submission.en_US
dc.identifier.doi10.3389/fmed.2024.1353354
dc.identifier.issn2296-858X
dc.identifier.pmid38741770en_US
dc.identifier.scopus2-s2.0-85192979725en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fmed.2024.1353354
dc.identifier.urihttps://hdl.handle.net/11454/104248
dc.identifier.volume11en_US
dc.identifier.wosWOS:001219207300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectAlopecia Areataen_US
dc.subjectDisease Burdenen_US
dc.subjectDiagnosisen_US
dc.subjectTreatmenten_US
dc.subjectClinical Managementen_US
dc.titleDisease burden, clinical management and unmet treatment need of patients with moderate to severe alopecia areata; consensus statements, insights, and practices from CERTAAE (Central/Eastern EU, Russia, Türkiye AA experts) Delphi panelen_US
dc.typeArticleen_US

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