The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey

Basit Öğe Kaydı
dc.contributor.authorTekin, Rahmi Tuna
dc.contributor.authorDinleyici, Ener Cagri
dc.contributor.authorCeyhan, Mehmet
dc.contributor.authorKarbuz, Adem
dc.contributor.authorSalman, Nuran
dc.contributor.authorSutcu, Murat
dc.contributor.authorKurugol, Zafer
dc.contributor.authorBalliel, Yasemin
dc.contributor.authorCelik, Melda
dc.contributor.authorHacimustafaoglu, Mustafa
dc.contributor.authorKuyucu, Necdet
dc.contributor.authorKondolot, Meda
dc.contributor.authorSensoy, Gulnar
dc.contributor.authorMetin, Ozge
dc.contributor.authorKara, Soner Sertan
dc.contributor.authorDinleyici, Meltem
dc.contributor.authorKilic, Omer
dc.contributor.authorBayhan, Cihangul
dc.contributor.authorGurbuz, Venhar
dc.contributor.authorAycan, Emre
dc.contributor.authorMemedova, Aygun
dc.contributor.authorKarli, Arzu
dc.contributor.authorBozlu, Gulcin
dc.contributor.authorCelebi, Solmaz
dc.date.accessioned2019-10-27T11:11:33Z
dc.date.available2019-10-27T11:11:33Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractThe serogroup epidemiology of invasive meningococcal disease (IMD), which varies considerably by geographic region and immunization schedule, changes continuously. Meningococcal carriage data are crucial for assessing IMD epidemiology and designing f potential vaccination strategies. Meningococcal seroepidemiology in Turkey differs from that in other countries: serogroups W and B are the predominant strains for IMD during childhood, whereas no serogroup C cases were identified over the last 10 y and no adolescent peak for IMD was found. There is a lack of data on meningococcal carriage that represents the whole population. The aims of this multicenter study (12 cities in Turkey) were to evaluate the prevalence of Neisseria meningitidis carriage, the serogroup distribution and the related risk factors (educational status, living in a dormitory or student house, being a household contact with Hajj pilgrims, smoking, completion of military service, attending bars/clubs) in 1518 adolescents and young adults aged 10-24 y. The presence of N. meningitidis DNA was tested, and a serogroup analysis was performed using polymerase chain reaction. The overall meningococcal carriage rate was 6.3% (n = 96) in the study population. A serogroup distribution of the 96 N. meningitidis strains isolated from the nasopharyngeal specimens revealed serogroup A in 5 specimens (5.2%), serogroup B in 9 specimens (9.4%), serogroup W in 64 specimens (66.6%), and serogroup Y in 4 specimens (4.2%); 14 were classified as non-grouped (14.4%). No serogroup C cases were detected. The nasopharyngeal meningococcal carriage rate was 5% in the 10-14 age group, 6.4% in the 15-17 age-group, and 4.7% in the 18-20 age group; the highest carriage rate was found in the 21-24 age group (9.1%), which was significantly higher than those of the other age groups (p < 0.05). The highest carriage rate was found in 17-year-old adolescents (11%). The carriage rate was higher among the participants who had had close contact with Hajj/Umrah pilgrims (p < 0.01) or a history of upper respiratory tract infections over the past 3 months (p < 0.05). The nasopharyngeal carriage rate was 6.3% among adolescents and young adults in Turkey and was similar to the recent rates observed in the same age groups in other countries. The most prevalent serogroup was W, and no serogroup C cases were found. In conclusion, the present study found that meningococcal carriage reaches its peak level by age 17, the highest carriage rate was found in 21-to 24-year-olds and the majority of the carriage cases were due to serogroup W. Adolescents and young adult carriers seem to be a potential reservoir for the disease, and further immunization strategies, including adolescent immunization, may play a role in the control of IMD.en_US
dc.description.sponsorshipScientific Research Projects of the Eskisehir Osmangazi University [2014/455]en_US
dc.description.sponsorshipThe study was fully financed by the Scientific Research Projects of the Eskisehir Osmangazi University (2014/455).en_US
dc.identifier.doi10.1080/21645515.2016.1268304en_US
dc.identifier.endpage1189en_US
dc.identifier.issn2164-5515
dc.identifier.issn2164-554X
dc.identifier.issue5en_US
dc.identifier.pmid28140784en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1182en_US
dc.identifier.urihttps://doi.org/10.1080/21645515.2016.1268304
dc.identifier.urihttps://hdl.handle.net/11454/32501
dc.identifier.volume13en_US
dc.identifier.wosWOS:000401516100041en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofHuman Vaccines & Immunotherapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectadolescentsen_US
dc.subjectmeningococcien_US
dc.subjectmeningococcal vaccinesen_US
dc.subjectnasopharyngeal colonizationen_US
dc.subjectNeisseria meningitidisen_US
dc.subjectTurkeyen_US
dc.titleThe prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkeyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu