Survival outcomes of women with grade 3 endometrioid endometrial cancer: the impact of adjuvant treatment strategies

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dc.authoridGungorduk, Kemal/0000-0002-2325-1756
dc.authorid/0000-0002-3351-9429
dc.authoridMuallem, Mustafa Zelal/0000-0003-4508-137X
dc.authoridMiranda, Andrea/0000-0001-5029-7365
dc.authorscopusid16645726200
dc.authorscopusid57215019944
dc.authorscopusid35519268800
dc.authorscopusid57189251133
dc.authorscopusid36106694700
dc.authorscopusid35588071900
dc.authorscopusid7003518921
dc.authorwosidGungorduk, Kemal/A-1163-2018
dc.contributor.authorGungorduk, Kemal
dc.contributor.authorMuallem, Jumana
dc.contributor.authorAsicioglu, Osman
dc.contributor.authorGulseren, Varol
dc.contributor.authorGulec, Umran Kucukgoz
dc.contributor.authorMeydanli, Mehmet Mutlu
dc.contributor.authorSehouli, Jalid
dc.date.accessioned2023-01-12T19:50:10Z
dc.date.available2023-01-12T19:50:10Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractAim This multicenter investigation was performed to evaluate the adjuvant treatment options, prognostic factors, and patterns of recurrence in patients with grade 3 endometrioid endometrial cancer (G3-EEC). Materials and methods The medical reports of patients undergoing at least total hysterectomy and salpingo-oophorectomy for G3-EEC between 1996 and 2018 at 11 gynecological oncology centers were analyzed. Optimal surgery was defined as removal of all disease except for residual nodules with a maximum diameter <= 1 cm, as determined at completion of the primary operation. Adequate systematic lymphadenectomy was defined as the removal of at least 15 pelvic and at least 5 paraaortic LNs. Results The study population consists of 465 women with G3-EEC. The 5-year disease-free survival (DFS) and overall survival (OS) rates of the entire cohort are 50.3% and 57.6%, respectively. Adequate systematic lymphadenectomy was achieved in 429 (92.2%) patients. Optimal surgery was achieved in 135 (75.0%) patients in advanced stage. Inadequate lymphadenectomy (DFS; HR 3.4, 95% CI 3.0-5.6; P = 0.016-OS; HR 3.2, 95% CI 1.6-6.5; P = 0.019) was independent prognostic factors for 5-year DFS and OS. Conclusion Inadequate lymphadenectomy and LVSI were independent prognostic factors for worse DFS and OS in women with stage I-II G3-EEC. Adequate lymphadenectomy and optimal surgery were independent prognostic factors for better DFS and OS in women with stage III-IV G3-EEC.en_US
dc.identifier.doi10.1007/s00404-021-06187-4
dc.identifier.endpage681en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue3en_US
dc.identifier.pmid34448946en_US
dc.identifier.scopus2-s2.0-85113601731en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage671en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-021-06187-4
dc.identifier.urihttps://hdl.handle.net/11454/76036
dc.identifier.volume305en_US
dc.identifier.wosWOS:000690372800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometrial adenocarcinomaen_US
dc.subjectGrade 3en_US
dc.subjectLymphadenectomyen_US
dc.subjectPhase-Iii Trialen_US
dc.subjectEarly-Stageen_US
dc.subjectCarcinomasen_US
dc.subjectLymphadenectomyen_US
dc.titleSurvival outcomes of women with grade 3 endometrioid endometrial cancer: the impact of adjuvant treatment strategiesen_US
dc.typeArticleen_US

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