In silico and in vitro evaluation of oxypeucedanin-induced anticancer activity: Mitotoxicity?

Basit Öğe Kaydı
dc.contributor.authorErgüç, Ali
dc.contributor.authorOkur, Hayati
dc.contributor.authorKarakuş, Fuat
dc.contributor.authorAlbayrak, Gökay
dc.contributor.authorArzuk, Ege
dc.contributor.authorBaykan, Şüra
dc.date.accessioned2024-08-31T07:31:30Z
dc.date.available2024-08-31T07:31:30Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: This study aims to evaluate the alterations in Oxypeucedanin (OXY)-mediated anticancer activity in different media. Second aim is to predict the affinity of OXY to electron transfer chain (ETC) complexes. Materials and Methods: MTT and LDH leakage assays were performed with OXY. Molecular docking studies were also conducted to predict the affinity of OXY to ETC complexes. Results: 250 µM OXY reduced viability in glucose media. ?50 µM OXY decreased viability in galactose media. ?50 µM OXY increased membrane disruption in galactose media. Molecular docking studies also showed that OXY might possess the capacity to bind to the inhibition sites of Complex I and IV. Conclusion: Galactose-conditioned media exacerbated the OXY-mediated cytotoxicity. Preliminary results suggested that mitotoxicity might take part in anticancer activity. Furthermore, OXY might cause ETC dysfunctions due to selective inhibition of Complex I and IV.en_US
dc.identifier.doi10.30569/adiyamansaglik.1325975
dc.identifier.endpage161en_US
dc.identifier.issn2458-9179
dc.identifier.issue3en_US
dc.identifier.startpage153en_US
dc.identifier.trdizinid1231556en_US
dc.identifier.urihttps://doi.org/10.30569/adiyamansaglik.1325975
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1231556
dc.identifier.urihttps://hdl.handle.net/11454/103482
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAdıyaman Üniversitesi Sağlık Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectOxypeucedaninen_US
dc.subjectMitotoxicityen_US
dc.subjectAnticancer activityen_US
dc.subjectIn silicoen_US
dc.titleIn silico and in vitro evaluation of oxypeucedanin-induced anticancer activity: Mitotoxicity?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu