Effects of H-2 receptor blocking agents on bacterial translocation in burn injury

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dc.contributor.authorAvanoglu, A
dc.contributor.authorHerek, O
dc.contributor.authorUlman, I
dc.contributor.authorErgun, O
dc.contributor.authorTunger, A
dc.contributor.authorAlkanat, M
dc.contributor.authorErdener, A
dc.date.accessioned2019-10-27T11:53:13Z
dc.date.available2019-10-27T11:53:13Z
dc.date.issued1997
dc.departmentEge Üniversitesien_US
dc.description14th Annual International Congress of the Turkish-Association-of-Pediatric-Surgeons -- SEP 26-30, 1995 -- DENIZLI, TURKEYen_US
dc.description.abstractWe experimentally studied the effects of Hz receptor blockers (ranitidine) on bacterial translocation (BT) in 42 male albino rats. Sham group (Group I, n = 12 rats) were exposed to 21 degrees C water while Burn group (Group II, n = 15 rats) and Ranitidine group (Group III, n = 15 rats) were exposed to 95 degrees C hot water for 10 seconds to produce a full thickness burn in 30% of total body surface area. 300 mg/kg ranitidine was administered to Group III starting immediately after the burn injury. Rats were sacrificed on the fifth postburn day. Sham group gained weight while groups II and III had significant weight loss. Gastric pH increased with the administration of ranitidine. Both gram negative and total number of bacteria were found to be reduced in cecal stool cultures in ranitidine group. Significant increase in BT was observed in Group III, and translocating bacteria were found to be different in burn and ranitidine groups with a final conclusion that administration of ranitidine changes intestinal ecological equilibrium and promotes BT.en_US
dc.description.sponsorshipTurkish Assoc Pediat Surgeonsen_US
dc.identifier.doi10.1055/s-2008-1071171en_US
dc.identifier.endpage281en_US
dc.identifier.issn0939-7248
dc.identifier.issue5en_US
dc.identifier.pmid9402485en_US
dc.identifier.startpage278en_US
dc.identifier.urihttps://doi.org/10.1055/s-2008-1071171
dc.identifier.urihttps://hdl.handle.net/11454/34864
dc.identifier.volume7en_US
dc.identifier.wosWOS:A1997YG60500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHippokrates Verlag Gmbhen_US
dc.relation.ispartofEuropean Journal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectburn injuryen_US
dc.subjectranitidineen_US
dc.subjectH-2 receptor blockersen_US
dc.subjectbacterial translocationen_US
dc.titleEffects of H-2 receptor blocking agents on bacterial translocation in burn injuryen_US
dc.typeArticleen_US

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