Metabolic comparison of radiolabeled bleomycin and bleomycin-glucuronide labeled with 99mTc

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dc.contributor.authorKoçan F.
dc.contributor.authorAvcíbaşí U.
dc.contributor.authorÜnak P.
dc.contributor.authorMüftüler F.Z.B.
dc.contributor.authorIçhedef Ç.A.
dc.contributor.authorDemiroglu H.
dc.contributor.authorGümüşer F.G.
dc.date.accessioned2019-10-27T08:33:32Z
dc.date.available2019-10-27T08:33:32Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractThe metabolic comparison of bleomycin (BLM) and bleomycin-glucuronide (BLMG) radiolabeled with 99mTc ( 99mTc-BLM and 99mTc-BLMG, respectively) has been investigated in this study. Quality control procedures were carried out using thin-layer radiochromatography and high-performance liquid chromatography. To compare the metabolic behavior of BLM and its glucuronide conjugate radiolabeled with 99mTc, scintigraphic, and biodistributional techniques were applied using male New Zealand rabbits and Albino Wistar rats. The results obtained have shown that these compounds were successfully radiolabeled with a labeling yield of about 100%. Maximum uptakes of 99mTc-BLM and 99mTc-BLMG metabolized as N-glucuronide were observed within 2 hours in the liver, the bladder, and the spinal cord for 99mTc-BLM and the lung, the liver, the kidney, the large intestine, and the spinal cord for 99mTc-BLMG, respectively. Scintigraphy and biodistributional studies performed on the experimental animals have shown that radiopharmaceutical potentials of these compounds are completely different. At the same time, uptake of the 99mTc-BLMG was found to be better than that of 99mTc-BLM. © 2011, Mary Ann Liebert, Inc.en_US
dc.identifier.doi10.1089/cbr.2011.0998en_US
dc.identifier.endpage584en_US
dc.identifier.issn1084-9785
dc.identifier.issue5en_US
dc.identifier.pmid21950554en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage573en_US
dc.identifier.urihttps://doi.org/10.1089/cbr.2011.0998
dc.identifier.urihttps://hdl.handle.net/11454/26804
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofCancer Biotherapy and Radiopharmaceuticalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject99mTcen_US
dc.subjectbiodistributionen_US
dc.subjectBLMen_US
dc.subjectBLMGen_US
dc.subjectglucuronidationen_US
dc.subjectradiolabelingen_US
dc.subjectscintigraphyen_US
dc.titleMetabolic comparison of radiolabeled bleomycin and bleomycin-glucuronide labeled with 99mTcen_US
dc.typeArticleen_US

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