Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with Behçet's disease

Basit Öğe Kaydı
dc.contributor.authorOksel F.
dc.contributor.authorKeser G.
dc.contributor.authorOzmen M.
dc.contributor.authorAksu K.
dc.contributor.authorKitapcioglu G.
dc.contributor.authorBerdeli A.
dc.contributor.authorDoganavsargil E.
dc.date.accessioned2019-10-27T00:09:23Z
dc.date.available2019-10-27T00:09:23Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective. The 894 G › T (Glu298Asp) polymorphism in exon 7 of the endothelial nitric oxide synthase (eNOS) gene was previously reported to be associated with Behçet's Disease (BD) susceptibility in Italian origin and Korean patients, but not in a group of unrelated Turkish patients. We analyzed whether this polymorphism is associated with BD, in another group of Turkish patients. Methods. We studied 132 consecutive Turkish BD patients being followed up by Ege University Rheumatology Department and 91 healthy controls. All individuals were genotyped by PCR-RFLP for 894 G › T in exon 7 (Glu298Asp). Results. The frequency of the T allele in BD group (101/264) was significantly higher than in healthy controls (OR 1.88, %95 CI 1.27-2.49, p < 0.001). The frequency of the homozygote (TT) Glu298Asp polymorphism in BD (27/132) was also significantly higher than in healthy controls (5/91) (OR 3.72, %95 CI 3.44-4.0, p < 0.001). However, no association was found between the Glu298Asp polymorphism and clinical parameters in BD. Conclusions. In this study, we found that Glu298Asp polymorphism of the eNOS gene was associated with BD in Turkish patients. © Copyright Clinical and Experimental Rheumatology 2006.en_US
dc.identifier.endpageS82en_US
dc.identifier.issn0392-856X
dc.identifier.issue5 SUPPL. 42en_US
dc.identifier.pmid17067432en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageS79en_US
dc.identifier.urihttps://hdl.handle.net/11454/21658
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofClinical and Experimental Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehçet's diseaseen_US
dc.subjectEndothelial nitric oxide synthase gene (eNOS)en_US
dc.subjectSingle-nucleotide polymorphismen_US
dc.titleEndothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with Behçet's diseaseen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu