Effect of polyethylene glycol 4000 on adhesion formation following thyroid surgery in rats

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dc.contributor.authorSakarya, A
dc.contributor.authorIlkgul, O
dc.contributor.authorAydede, H
dc.contributor.authorErhan, Y
dc.contributor.authorIcoz, G
dc.contributor.authorKapkac, M
dc.contributor.authorAlkanat, M
dc.contributor.authorKara, E
dc.date.accessioned2019-10-27T18:17:25Z
dc.date.available2019-10-27T18:17:25Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground & objectives: Difficulties in dissection encountered during. reoperative thyroid surgery could be minimised by preventing formation of adhesions in the,operative field. We studied the prevention of adhesion formation in rats after thyroid surgery by using polyethylene glycol 4000 (PEG 4000). Methods: Twenty two rats in two equal groups were studied. Right hemithyroidectomy was performed in both groups with 0.9 per cent saline being instilled in. the operative field in the control group and PEG 4000 solution in the study group. After 10 days, all rats were re-explored and the remaining thyroid tissue of the right lobe was excised. The specimens were scored according to the thickness of the connective tissue over the remainder of the thyroid gland. Results: The connective tissue thickness over the remaining tissue of the thyroid gland in the control and study groups was 272.04 +/- 77.10 and 172.90 +/- 48.92 mum respectively. The decrease of the connective tissue thickness over, the remainder of thyroid gland in the study group Was significant (P<0.05). Interpretation & conclusion: In this animal model although application of PEG 4000 did not completely prevent adhesion formation, a significantly decreased amount of adhesions was found.en_US
dc.identifier.endpage259en_US
dc.identifier.issn0971-5916
dc.identifier.pmid12440198en_US
dc.identifier.startpage255en_US
dc.identifier.urihttps://hdl.handle.net/11454/35339
dc.identifier.volume115en_US
dc.identifier.wosWOS:000178996600005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIndian Council Medical Resen_US
dc.relation.ispartofIndian Journal of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadhesionen_US
dc.subjectpolyethylene glycol 4000en_US
dc.subjectthyroid surgeryen_US
dc.titleEffect of polyethylene glycol 4000 on adhesion formation following thyroid surgery in ratsen_US
dc.typeArticleen_US

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