Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model

Basit Öğe Kaydı
dc.contributor.authorMermer, Sinan
dc.contributor.authorTurhan, Tuncer
dc.contributor.authorBolat, Elif
dc.contributor.authorAydemir, Sohret
dc.contributor.authorYamazhan, Tansu
dc.contributor.authorPullukcu, Husnu
dc.contributor.authorSipahi, Oguz Resat
dc.date.accessioned2020-12-01T11:58:19Z
dc.date.available2020-12-01T11:58:19Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: the aim of this study was to compare the antibacterial activity of ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis in an experimental rabbit meningitis model. Methods: the antibacterial activity of ceftaroline was compared with vancomycin in the treatment of meningitis induced by MRSA strain ATCC 43300 in an experimental rabbit meningitis model. Quantitative cerebrospinal fluid (CSF) cultures were performed at the beginning of antibiotic treatment and 24 h and 73 h after the first antibiotic dose. Furthermore, in vitro time-kill data were investigated at 0, 2, 4, 6, 8, 12 and 24 h in sterile human serum. Results: the difference between the control group versus both treatment groups was significant when comparing the decrease in colony counts in CSF both at 24 h and 73 h after the first antibiotic dose (P < 0.05). At the end of the experiment, there was a significant difference in survival between both the ceftaroline-treated group and the vancomycin-treated group versus the control group, but not between the two treatment groups. Conclusion: These results suggest that the antibacterial activity of both ceftaroline and vancomycin are similar in the treatment of MRSA meningitis in an experimental rabbit meningitis model. (C) 2020 the Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.en_US
dc.description.sponsorshipEge University (Izmir, Turkey)Ege Universityen_US
dc.description.sponsorshipThis study was funded by Ege University (Izmir, Turkey).en_US
dc.identifier.doi10.1016/j.jgar.2020.02.001en_US
dc.identifier.endpage151en_US
dc.identifier.issn2213-7165
dc.identifier.issn2213-7173
dc.identifier.pmid32068093en_US
dc.identifier.scopus2-s2.0-85086748046en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage147en_US
dc.identifier.urihttps://doi.org/10.1016/j.jgar.2020.02.001
dc.identifier.urihttps://hdl.handle.net/11454/61982
dc.identifier.volume22en_US
dc.identifier.wosWOS:000572257300022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Global Antimicrobial Resistanceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNosocomial meningitisen_US
dc.subjectMethicillin-resistant staphylococcien_US
dc.subjectCentral nervous system infectionen_US
dc.subjectGlycopeptidesen_US
dc.subjectAnimal modelen_US
dc.subjectPharmacokineticsen_US
dc.titleCeftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu