Denosumab-Related Osteonecrosis of the Jaw with Actinomycosis Infection and Extensive Periosteal Reaction

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Tarih

2024

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Medication-related osteonecrosis of the jaws (MRONJ) is a well-known side effect of bisphosphonate drugs used in the treat- ment of osteometabolic disorders and some types of cancer. However, development of MRONJ have also been reported in patients using denosumab, a monoclonal immunoglobulin G2 antibody inhibiting os- teoclastic bone resorption. Even though denosumab is more advanta- geous than bisphosphonates due to its shorter half-life and lack of binding to the bone, MRONJ has accepted as a well-known side-effect of denosumab as it is in bisphosphonates. We reported clinical, radio- graphic, and histopathological findings of a female patient who devel- oped osteonecrosis of the jaw following denosumab treatment and presented with actinomycosis infection and extensive periosteal new bone formation. Our case emphasized the importance of dental screen- ing before initiating and during denosumab treatment in order to pre- vent and lower the risk of MRONJ development.

Açıklama

Anahtar Kelimeler

Actinomyces, actinomycosis, denosumab, mandible, osteonecrosis

Kaynak

Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi

WoS Q Değeri

Scopus Q Değeri

Cilt

30

Sayı

2

Künye