Denosumab-Related Osteonecrosis of the Jaw with Actinomycosis Infection and Extensive Periosteal Reaction
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Medication-related osteonecrosis of the jaws (MRONJ) is a well-known side effect of bisphosphonate drugs used in the treat- ment of osteometabolic disorders and some types of cancer. However, development of MRONJ have also been reported in patients using denosumab, a monoclonal immunoglobulin G2 antibody inhibiting os- teoclastic bone resorption. Even though denosumab is more advanta- geous than bisphosphonates due to its shorter half-life and lack of binding to the bone, MRONJ has accepted as a well-known side-effect of denosumab as it is in bisphosphonates. We reported clinical, radio- graphic, and histopathological findings of a female patient who devel- oped osteonecrosis of the jaw following denosumab treatment and presented with actinomycosis infection and extensive periosteal new bone formation. Our case emphasized the importance of dental screen- ing before initiating and during denosumab treatment in order to pre- vent and lower the risk of MRONJ development.
Açıklama
Anahtar Kelimeler
Actinomyces, actinomycosis, denosumab, mandible, osteonecrosis
Kaynak
Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
30
Sayı
2
