A novel theranostic nanobioconjugate: I-125/131 labeled phenylalanine conjugated boron nitride nanotubes
Küçük Resim Yok
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Here we report the synthesis of boron nitride nanotubes (BNNTs) via a chemical vapor deposition method, as potential agents for boron neutron capture therapy. BNNTs were functionalized with PAMAM[G-2] dendrimer and then, conjugated with L-Phe using EDC/NHS. After that, BNNTs were radiolabeled with I-125/131, which are commonly used for both therapy and diagnosis in clinical and pre-clinical studies. BNNTs were radiolabeled with a maximum yield with I-125/131 in compared with 4-borono-L-phenyalanine which is currently used as a commercial drug. Radiolabeling parameters were optimized with thin layer radiochromatography and high performance liquid radiochromatography. BNNTs are promising nanobioconjugates as new theranostic agents.
Açıklama
Anahtar Kelimeler
Boron nitride nanotube (BNNT), Chemical vapor deposition (CVD), Poly amido amid dendrimer (PAMAM[G2]), Radioiodination, I-125, I-131
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
311
Sayı
3
