A novel theranostic nanobioconjugate: I-125/131 labeled phenylalanine conjugated boron nitride nanotubes

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dc.contributor.authorGuldu, Ozge Kozgus
dc.contributor.authorUnak, Perihan
dc.contributor.authorTimur, Suna
dc.date.accessioned2019-10-27T11:10:20Z
dc.date.available2019-10-27T11:10:20Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractHere we report the synthesis of boron nitride nanotubes (BNNTs) via a chemical vapor deposition method, as potential agents for boron neutron capture therapy. BNNTs were functionalized with PAMAM[G-2] dendrimer and then, conjugated with L-Phe using EDC/NHS. After that, BNNTs were radiolabeled with I-125/131, which are commonly used for both therapy and diagnosis in clinical and pre-clinical studies. BNNTs were radiolabeled with a maximum yield with I-125/131 in compared with 4-borono-L-phenyalanine which is currently used as a commercial drug. Radiolabeling parameters were optimized with thin layer radiochromatography and high performance liquid radiochromatography. BNNTs are promising nanobioconjugates as new theranostic agents.en_US
dc.description.sponsorshipEge University Scientific Research FundEge University [2015 NBE 002]en_US
dc.description.sponsorshipThe authors thank to the Ege University Scientific Research Fund for the financial support through the project number 2015 NBE 002. Associate Professor Arzu Turkler Ege and Associate Professor Mehmet Ayvacikli from Celal Bayar University are acknowledged for their valuable helps during the synthesis step of BNNTs. Dr Hasan Demiroglu from Celal Bayar University is acknowledged for his helps during FTIR measurements.en_US
dc.identifier.doi10.1007/s10967-016-5127-4
dc.identifier.endpage1762en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue3en_US
dc.identifier.startpage1751en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-016-5127-4
dc.identifier.urihttps://hdl.handle.net/11454/32386
dc.identifier.volume311en_US
dc.identifier.wosWOS:000398027800022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBoron nitride nanotube (BNNT)en_US
dc.subjectChemical vapor deposition (CVD)en_US
dc.subjectPoly amido amid dendrimer (PAMAM[G2])en_US
dc.subjectRadioiodinationen_US
dc.subjectI-125en_US
dc.subjectI-131en_US
dc.titleA novel theranostic nanobioconjugate: I-125/131 labeled phenylalanine conjugated boron nitride nanotubesen_US
dc.typeArticleen_US

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