Development and Evaluation of Liquid and Solid Lipid Based Drug Delivery Systems Containing Technetium-99m-Radiolabeled Alendronate Sodium
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bentham Science Publ Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The purpose of this study was to develop lipid-water based drug delivery system of Alendronate Sodium (ALD) in liquid and solid form obtained by using spray drying method and compare these two forms with radioactive cell culture studies. Methods: This study included the development of liquid and solid form obtained by spray drying method, radiolabelling of ALD with Tc-99m, preparation of formulations containing Tc-99m-ALD and evaluation of their permeability with Caco-2 cell. The liquid formulations have been developed by using various surfactants, co-surfactants, oil and water phases. Physicochemical characterizations like droplet size, polydispersity index (PDI) and zeta potential measurements and short term stability studies were investigated. Results: According to the measurement results, two oil in water formulations (F1-L and F2-L) were selected and spray dried with Buchi mini spray dryer apparatus to provide solid formulations (F -S and F2-S). ALD was labeled with Tc-99m and added to formulations. The effect of experimental conditions on radiolabeling efficiency of ALD and stability of all formulations containing Tc-99m-ALD were investigated through Radio Thin Layer Chromatography (RTLC). It was observed that the labeling efficiency of ALD was greater than 90% and all formulations were found to be stable up to 6 h at room temperature. Permeability of radiolabeled ALD from all formulations was performed by using Caco-2 cells. According to the cell culture studies, permeability from spray dried formulations of ALD was found higher than liquid formulations. Conclusion: As a conclusion, spray dried formulations could be a promising drug delivery system for enhancing the permeability of ALD. Furthermore, this study is a good example of the use of radio-labeled compounds in drug development.
Açıklama
Anahtar Kelimeler
Spray drying method, lipid-water based drug delivery system, technetium-99m, radiolabeling, alendronate sodium, RTLS
Kaynak
Current Radiopharmaceuticals
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
11
Sayı
2
