Hydroxyethyl starch solution: Is it a new alternative way of treatment in bacterial translocation?

Basit Öğe Kaydı
dc.contributor.authorTiras, S
dc.contributor.authorYilmaz, R
dc.contributor.authorErsin, S
dc.contributor.authorKara, E
dc.contributor.authorOzbal, O
dc.contributor.authorOzdedeli, E
dc.contributor.authorKapkac, M
dc.date.accessioned2019-10-27T11:51:52Z
dc.date.available2019-10-27T11:51:52Z
dc.date.issued1998
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this experimental study, the effects of mannitol and hydroxyethyl starch solution (HES) on bacterial translocation were evaluated in a rat model of simple mechanical bowel obstruction. The mechanical bowel obstruction was created by ligation of the ileum 1 cm proximal to the ileocecal valve, Excluding the control group (n=7), the rats were given 2 mi of mannitol or 2 mi of 6% hydroxyethyl starch solution intraperitoneally during the procedure. Relaparotomy was made and segmental heal resection, total mesenteric lymph node excision and removal of tissue sample of liver were performed 24 h after the mechanical bowel obstruction, both for histopathological and microbiological examination. The rates of colony formation in the mesenteric lymph nodes after the mechanical bowel obstruction were 71% (5/7) in control animals, 43% (3/7) in animals given mannitol and only 14% (1/7) in animals given HES, In the liver samples observed for the bacterial translocation, the corresponding figures were 14% (1/7), 28% (2/7) and 0% (0/7) respectively, The difference between hydroxyethyl starch solution and control groups were statistically significant (P < 0.04), The bacterial population/g tissue obtained from intraluminal bacterial cultures of the ileum was also depressed in hydroxyethyl starch solution group when compared to the control (P < 0.03), As a result, we confirmed that hydroxyethyl starch solution, a plasma volume expander, depressed the bacterial translocation to the mesenteric lymph nodes and liver and also reduced intraluminal bacterial overgrowth in the simple mechanical bowel obstruction model of rats. We believe that hydroxyethyl starch solution may be an alternative therapeutic agent for the pre-operative fluid resuscitation in simple mechanical bowel obstruction.en_US
dc.identifier.endpage252en_US
dc.identifier.issn0020-8868
dc.identifier.issue3en_US
dc.identifier.pmid9870785en_US
dc.identifier.startpage250en_US
dc.identifier.urihttps://hdl.handle.net/11454/34647
dc.identifier.volume83en_US
dc.identifier.wosWOS:000077220900017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofInternational Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbacterial translocationen_US
dc.subjectmechanical bowel obstructionen_US
dc.subjecthydroxyethyl starch solutionen_US
dc.titleHydroxyethyl starch solution: Is it a new alternative way of treatment in bacterial translocation?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu