The potential antioxidant effect of raloxifene treatment: a study on heart, liver and brain cortex of ovariectomized female rats

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dc.contributor.authorKonyalioglu, Sibel
dc.contributor.authorDurmaz, Guliz
dc.contributor.authorYalcin, Ayfer
dc.date.accessioned2019-10-27T19:34:46Z
dc.date.available2019-10-27T19:34:46Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractThe antioxidant activity of some compounds buffer the free radicals generated either endogenously or exogenously, thus decreasing the potential damage mediated by oxidation. Recent studies documented that raloxifene has antioxidant properties in vitro. However, there are limited animal studies available to show raloxifene's antioxidant properties. We aimed to investigate the effects of raloxifene on antioxidant enzymes such as SOD, CAT and GPX, TrxR and the levels of GSH and MDA in heart, liver and brain cortex of ovariectomized female rats. Female Sprague Dawley rats weighing 300-350 g (n = 24) were divided into three groups: (I) Eight non-ovariectomized rats were used as naive controls without any treatment (non-ovariectomized group, n = 8). Five weeks after ovariectomy, (II) Ovariectomized placebo group (n = 8) was given physiological saline, and (III) Raloxifene group (n = 8) was given raloxifene 1 mg/kg sc. daily for 12 days. Ovariectomy induced significant increases on SOD, GPX, CAT activity and MDA levels in brain, heart and liver tissues compared to non-ovariectomized rats (p < 0.05). Raloxifene treatment led to decreased levels of SOD activity in heart, GPX activity in brain and CAT activity in liver tissue when compared to ovariectomized group (p < 0.05) but there was no change in activity of TrxR in all groups. The levels of MDA in brain, heart and liver tissues increased in ovariectornized group when compared to non-overiectomized rats (p < 0.05). Raloxifene had a significant attenuating effect on the levels of MDA in brain and heart tissues. Our results also indicate that the levels of GSH in brain, heart and liver tissue decreased when compared to non-ovariectomized rats. Raloxifene treatment was observed to significantly increase the levels of GSH in brain and heart tissues (p < 0.05). However, there were insignificant differences for the GSH levels in liver tissues of ovariectornized placebo or raloxifene groups. In conclusion, our results demonstrate that raloxifene may be more effective against oxidative stress in heart and brain than in liver tissue. Copyright (c) 2006 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1328en_US
dc.identifier.endpage266en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue3en_US
dc.identifier.pmid16927419en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage259en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1328
dc.identifier.urihttps://hdl.handle.net/11454/39648
dc.identifier.volume25en_US
dc.identifier.wosWOS:000246778000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectraloxifeneen_US
dc.subjectselective estrogen receptor modulatorsen_US
dc.subjectantioxidant enzymesen_US
dc.subjectlipid peroxidationen_US
dc.subjectglutathioneen_US
dc.subjectovariectomyen_US
dc.titleThe potential antioxidant effect of raloxifene treatment: a study on heart, liver and brain cortex of ovariectomized female ratsen_US
dc.typeArticleen_US

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