Investigation of maternal melatonin effect on the hippocampal formation of newborn rat model of intrauterine cortical dysplasia

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dc.contributor.authorBaka, Meral
dc.contributor.authorUyanikgil, Yigit
dc.contributor.authorAtes, Utku
dc.contributor.authorKultursay, Nilgun
dc.date.accessioned2019-10-27T21:14:03Z
dc.date.available2019-10-27T21:14:03Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives Cortical dysplasia is a cortical malformation resulting from any developmental defects during different periods of development. This study aims to investigate the hippocampal histopathological alterations in the neonates with cortical dysplasia due to the prenatal exposure to carmustine (1,3-bis (2-chloroethyl)-1-nitrosoure; BCNU) and the possible effects of prophylaxis with melatonin, a neuroprotective agent. Methods Wistar albino female rats were randomly divided into four experimental groups; control, melatonin-treated, BCNU-exposed and BCNU-exposed+melatonin-treated. Light microscopy and immunohistochemistry were carried out on the newborn hippocampus. Results Histopathology of hippocampus from the control and melatonin-treated groups showed continuity of migration and maturation as patognomonic signs of the normal newborn hippocampus. Hippocampal cortex from the newborns exposed in utero to BCNU showed the histology of early embryonic hippocampal formation with immuno-histochemical increase in the number of nestin positive cells and decreases in the immunoreactivity of glial fibrillary acidic protein (GFAP) and synaptophysin. These findings indicate a significant delay in hippocampal maturation, migration, and synaptogenesis. Intrauterine treatment of BCNU-exposed rats with melatonin resulted in histopathological features almost similar to control group. Conclusion It has been concluded that cortical dysplasia induced by intrauterine BCNU administration results in delayed hippocampal maturation, which is successfully restored by intrauterine melatonin treatment.en_US
dc.identifier.doi10.1007/s00381-010-1147-5en_US
dc.identifier.endpage1581en_US
dc.identifier.issn0256-7040
dc.identifier.issn1433-0350
dc.identifier.issue11en_US
dc.identifier.pmid20461523en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1575en_US
dc.identifier.urihttps://doi.org/10.1007/s00381-010-1147-5
dc.identifier.urihttps://hdl.handle.net/11454/43325
dc.identifier.volume26en_US
dc.identifier.wosWOS:000284470700019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofChilds Nervous Systemen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCortical dysplasiaen_US
dc.subjectHippocampusen_US
dc.subjectMelatoninen_US
dc.subjectNewbornen_US
dc.subjectPregnancyen_US
dc.subjectRaten_US
dc.titleInvestigation of maternal melatonin effect on the hippocampal formation of newborn rat model of intrauterine cortical dysplasiaen_US
dc.typeArticleen_US

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