The regulatory effects of clomiphene and tamoxifen on mTOR and LC3-II expressions in relation to autophagy in experimental polycystic ovary syndrome (PCOS)

Basit Öğe Kaydı
dc.authoridKUŞÇU, Gökçe Ceren/0000-0003-1750-8209
dc.authoridYavasoglu, Altug/0000-0003-4227-1637
dc.authoridKarabay Yavasoglu, N.Ulku/0000-0002-7483-0184
dc.authoridBUHUR, Aylin/0000-0002-3759-6616
dc.authorscopusid57208213974
dc.authorscopusid57208215503
dc.authorscopusid57207940063
dc.authorscopusid55318033800
dc.authorscopusid12796347400
dc.authorscopusid6701658370
dc.authorscopusid8633854100
dc.authorwosidKUŞÇU, Gökçe Ceren/B-6557-2016
dc.authorwosidGUREL, ÇEVİK/AAA-1277-2021
dc.authorwosidKOSE, Timur/ABH-3197-2021
dc.contributor.authorKuscu, Gokce Ceren
dc.contributor.authorGurel, Cevik
dc.contributor.authorBuhur, Aylin
dc.contributor.authorOltulu, Fatih
dc.contributor.authorAkman, Levent
dc.contributor.authorKose, Timur
dc.contributor.authorYavasoglu, Nefise Ulku Karabay
dc.date.accessioned2023-01-12T19:50:48Z
dc.date.available2023-01-12T19:50:48Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground Polycystic ovary syndrome (PCOS) is a metabolic disease that causes infertility due to anovulation in women in reproductive age. It is known that clomiphene citrate (CC) and tamoxifen citrate (TMX) induce ovulation in women with PCOS. In this study, we aimed to investigate the effects of CC and TMX on the autophagy pathway in PCOS. Methods and results Experimental PCOS model was induced by letrozole (1 mg/kg) in rats by gavage for 21 days. After the last letrozole administration, rats were treated TMX (1 mg/kg) or CC (1 mg/kg) for 5 days. At the end of the experimental procedures, rats in all groups were sacrificed and ovarian tissues were removed. It was observed that mRNA and protein expressions of LC3-II were significantly higher in TMX and CC groups than control and PCOS groups (p < 0.05), while mRNA and protein expressions of mTOR in TMX and CC groups were found significantly lower than control and PCOS groups (p < 0.05). Conclusions In conclusion, present study suggests that TMX and CC induce autophagy in ovaries with PCOS. Autophagy is a promising target for understanding pathophysiology of this disease and for developing more effective and safe new protocols for the treatment of PCOS-related anovulation.en_US
dc.description.sponsorshipEge University Research Fund [BAP-17-TIP-029]en_US
dc.description.sponsorshipThis study was supported by the Ege University Research Fund [Grant number BAP-17-TIP-029 (to Altug Yavasoglu)].en_US
dc.identifier.doi10.1007/s11033-021-06981-y
dc.identifier.endpage1729en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue3en_US
dc.identifier.pmid34813001en_US
dc.identifier.scopus2-s2.0-85119837143en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1721en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-021-06981-y
dc.identifier.urihttps://hdl.handle.net/11454/76171
dc.identifier.volume49en_US
dc.identifier.wosWOS:000721666100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPCOSen_US
dc.subjectClomipheneen_US
dc.subjectTamoxifenen_US
dc.subjectAutophagyen_US
dc.subjectLC3-IIen_US
dc.subjectmTORen_US
dc.subjectOvulation Inductionen_US
dc.subjectCell-Deathen_US
dc.subjectCitrateen_US
dc.subjectWomenen_US
dc.subjectManagementen_US
dc.subjectGeneen_US
dc.titleThe regulatory effects of clomiphene and tamoxifen on mTOR and LC3-II expressions in relation to autophagy in experimental polycystic ovary syndrome (PCOS)en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu