Investigating the Effects of a Synthetic Cannabinoid on the Pathogenesis of Leukemia and Leukemic Stem Cells: A New Therapeutic Approach

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dc.authoridAslan, Rukiye/0000-0002-4012-3684
dc.authoridSALCIN, Hilal/0000-0002-9172-480X
dc.authorwosidBiray Avcı, Cigir/GWV-1665-2022
dc.authorwosidAslan, Rukiye/W-2331-2017
dc.contributor.authorSalcin, Hilal
dc.contributor.authorGoker Bagca, Bakiye
dc.contributor.authorAlcitepe, Ilayda
dc.contributor.authorBiray Avci, Cigir
dc.contributor.authorAslan, Rukiye
dc.contributor.authorAnnette Akgur, Serap
dc.contributor.authorTezcanli Kaymaz, Burcin
dc.date.accessioned2023-01-12T20:00:13Z
dc.date.available2023-01-12T20:00:13Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractThe popularity and usage of synthetic cannabinoids (SCs) are increasing due to their easy accessibility and psychoactive effects worldwide. Studies on cannabinoids on leukemic stem cells (LSC) and hematopoietic stem cells (HSCs), which are the precursors of leukemia cells, generally depend on the natural cannabinoid delta-9-THC. As there is only a limited number of studies focusing on the results of SC applications, the reflections upon LSCs have to be clarified. In this study, biological responses and antileukemic effects of JWH-018-one of the first produced and widely used SCs-were evaluated upon leukemia cells. Whether JWH-018 exhibited a preventive effect on both leukemic and HSCs was evaluated by presenting a therapeutic approach for the first time in the literature. Cells were analyzed in case of cell proliferation, apoptosis, and transcriptional expression profiling of some significant JAK/STAT and AKT/mTOR pathways, apoptotic, cell cycle regulation, and epigenetic chromatin remodeling-related genes following JWH-018 treatment. In conclusion, however, further studies are still needed upon both HSCs and LSCs to illuminate the effects of SCs on leukemogenesis on chronic myeloid leukemia (CML) more clearly; we consider that the JWH-018 can provide a therapeutic effect on the pathogenesis of leukemia and particularly upon LSCs and SCs might have therapeutic potential in addition to current therapy.en_US
dc.identifier.doi10.1089/can.2021.0180
dc.identifier.issn2578-5125
dc.identifier.issn2378-8763
dc.identifier.pmid35834597en_US
dc.identifier.urihttps://doi.org/10.1089/can.2021.0180
dc.identifier.urihttps://hdl.handle.net/11454/77304
dc.identifier.wosWOS:000827709300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofCannabis and Cannabinoid Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsynthetic cannabinoiden_US
dc.subjectJWH-018en_US
dc.subjectleukemiaen_US
dc.subjectleukemia stem cellsen_US
dc.subjectJAKen_US
dc.subjectSTATen_US
dc.subjectAKTen_US
dc.subjectmTORen_US
dc.subjectepigeneticen_US
dc.subjectchromatin remodelingen_US
dc.subjecttherapeutic approachen_US
dc.subjectActivationen_US
dc.subjectInhibitorsen_US
dc.subjectCanceren_US
dc.titleInvestigating the Effects of a Synthetic Cannabinoid on the Pathogenesis of Leukemia and Leukemic Stem Cells: A New Therapeutic Approachen_US
dc.typeArticleen_US

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