Therapy, outcome and analysis of c-kit expression in patients with extrapulmonary small cell carcinoma

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dc.contributor.authorKurt, E
dc.contributor.authorSezgin, C
dc.contributor.authorEvrensel, T
dc.contributor.authorYalcinkaya, U
dc.contributor.authorKanat, O
dc.contributor.authorVeral, A
dc.contributor.authorDemiray, M
dc.contributor.authorArslan, M
dc.contributor.authorKarabulut, B
dc.contributor.authorErcan, I
dc.contributor.authorGoker, E
dc.contributor.authorManavoglu, O
dc.date.accessioned2019-10-27T18:58:15Z
dc.date.available2019-10-27T18:58:15Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, we aimed to investigate the clinicopathological characteristics with special emphasis on c-kit expression and the treatment results of patients with extrapulmonary small cell carcinoma (EPSCC). The medical records of the patients with EPSCC were reviewed, and the data regarding patient and tumour characteristics, treatment and clinical outcome were retrieved and analysed. A total of 28 patients with the diagnosis of EPSCC were identified. There were 19 males and 9 females, with a mean age of 56.5 years. Patients with limited disease (LD) (n = 13) were treated with surgery, chemotherapy (CT) and radiotherapy with different sequences. Patients with extensive disease (ED) (n = 15) were mainly treated with combination CT. The median overall survival was 14.5 months in patients with LD compared to 11 months in those with ED (p = 0.029). Ten patients (36%) showed c-kit overexpression. There was no significant difference between the survival of c-kit-positive and c-kit-negative patients (p = 0.367). In conclusion, our study demonstrates that the prognosis of EPSCC is poor despite currently available treatments. C-kit may be considered as a potential target for novel therapeutical approaches.en_US
dc.identifier.doi10.1111/j.1368-5031.2005.00447.xen_US
dc.identifier.endpage543en_US
dc.identifier.issn1368-5031
dc.identifier.issue5en_US
dc.identifier.pmid15857349en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage537en_US
dc.identifier.urihttps://doi.org/10.1111/j.1368-5031.2005.00447.x
dc.identifier.urihttps://hdl.handle.net/11454/37438
dc.identifier.volume59en_US
dc.identifier.wosWOS:000228307200008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectextrapulmonaryen_US
dc.subjectsmall cell carcinomaen_US
dc.subjecttherapyen_US
dc.subjectc-kiten_US
dc.titleTherapy, outcome and analysis of c-kit expression in patients with extrapulmonary small cell carcinomaen_US
dc.typeArticleen_US

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