Mu opioid receptor mRNA expression, binding, and functional coupling to G-proteins in human epileptic hippocampus

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dc.contributor.authorCuellar-Herrera, Manola
dc.contributor.authorLuisa Velasco, Ana
dc.contributor.authorVelasco, Francisco
dc.contributor.authorChavez, Laura
dc.contributor.authorOrozco-Suarez, Sandra
dc.contributor.authorArmagan, Guliz
dc.contributor.authorTurunc, Ezgi
dc.contributor.authorBojnik, Engin
dc.contributor.authorYalcin, Ayfer
dc.contributor.authorBenyhe, Sandor
dc.contributor.authorBorsodi, Anna
dc.contributor.authorAlonso-Vanegas, Mario
dc.contributor.authorRocha, Luisa
dc.date.accessioned2019-10-27T21:44:49Z
dc.date.available2019-10-27T21:44:49Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractMu opioid receptors (MOR) are known to be involved in seizure activity. The main goal of the present study was to characterize the MOR mRNA expression, binding, as well as G protein activation mediated by these receptors in epileptic hippocampus of patients with pharmacoresistant mesial temporal lobe epilepsy (TLE). In contrast with autopsy samples, hippocampus obtained from patients with mesial TLE demonstrated enhanced MOR mRNA expression (116%). Saturation binding experiments revealed significantly higher (60%) Bmax values for the mesial TLE group, whereas the Kd values were not statistically different. Although mesial TLE group demonstrated high levels of basal binding for the G proteins (136%), DAMGO-stimulated [35S]GTP?S binding did not demonstrate significant alterations. In conclusion, our present data provide strong evidence that the epileptic hippocampus of patients with pharmacoresistant mesial TLE presents significant alterations in MOR. Such changes may represent adaptive mechanisms to compensate for other as yet unknown alterations. (C) 2010 Wiley Periodicals, Inc.en_US
dc.description.sponsorshipNational Council for Sciences and Technology of Mexico [J110.0130/2009, 98386]; National Institute of Science and Technology of Distrito Federal, Academy of Sciences of Hungary [ETT577/2006, RET67/2005]; Technological and Scientific Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [106S249]; Hungarian-Turkish project [11-06]en_US
dc.description.sponsorshipGrant sponsor: National Council for Sciences and Technology of Mexico; Grant numbers: J110.0130/2009, 98386; Grant sponsor: National Institute of Science and Technology of Distrito Federal, Academy of Sciences of Hungary; Grant numbers: ETT577/2006, RET67/2005; Grant sponsor: Technological and Scientific Council of Turkey (TUBITAK); Grant number: 106S249; Grant sponsor: Hungarian-Turkish project 11-06.en_US
dc.identifier.doi10.1002/hipo.20891en_US
dc.identifier.endpage127en_US
dc.identifier.issn1050-9631
dc.identifier.issue2en_US
dc.identifier.pmid21049484en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.1002/hipo.20891
dc.identifier.urihttps://hdl.handle.net/11454/47299
dc.identifier.volume22en_US
dc.identifier.wosWOS:000299250400002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofHippocampusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmu opiod receptoren_US
dc.subjectmRNAen_US
dc.subjectG-proteinen_US
dc.subjectbindingen_US
dc.subjecthippocampusen_US
dc.subjectmesial temporal lobe epilepsyen_US
dc.titleMu opioid receptor mRNA expression, binding, and functional coupling to G-proteins in human epileptic hippocampusen_US
dc.typeArticleen_US

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