Tachycardia-Induced Cardiomyopathy in Patients With Idiopathic Ventricular Arrhythmias: The Incidence, Clinical and Electrophysiologic Characteristics, and the Predictors

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dc.contributor.authorHasdemir, Can
dc.contributor.authorUlucan, Cem
dc.contributor.authorYavuzgil, Oguz
dc.contributor.authorYuksel, Alper
dc.contributor.authorKartal, Yildirim
dc.contributor.authorSimsek, Evrim
dc.contributor.authorMusayev, Oktay
dc.contributor.authorKayikcioglu, Meral
dc.contributor.authorPayzin, Serdar
dc.contributor.authorKultursay, Hakan
dc.contributor.authorAydin, Mehmet
dc.contributor.authorCan, Levent H.
dc.date.accessioned2019-10-27T21:24:11Z
dc.date.available2019-10-27T21:24:11Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractIdiopathic Ventricular Arrhythmias and Cardiomyopathy. Introduction: Idiopathic ventricular arrhythmias in the form of monomorphic premature ventricular contractions (PVC) and/or ventricular tachycardia (VT) can cause tachycardia-induced cardiomyopathy (TICMP). The aim of this study was to determine the incidence, clinical and electrophysiologic characteristics, and the predictors of TICMP in patients with idiopathic ventricular arrhythmias. Methods: Study population consisted of 249 consecutive patients (148 F/101 M, 45 +/- 20 y/o) with frequent PVCs and/or VT. All patients underwent transthoracic echocardiography and 24-hour Holter monitoring. TICMP was defined as left ventricular ejection fraction (LVEF) of <= 50% in the absence of any detectable underlying heart disease and improvement of LVEF >= 15% following effective treatment of index ventricular arrhythmia. Results: Seventeen (6.8%) patients had TICMP. Patients with TICMP compared to patients with preserved LVEF were more likely to be male (65% vs 39%, P = 0.043) and asymptomatic (29% vs 9%, P = 0.018), and were more likely to have higher PVC burden (29.4 +/- 9.2 vs 8.1 +/- 7.4, P < 0.001), persistence of PVCs throughout the day (65% vs 22%, P = 0.001), and repetitive monomorphic VT (24% vs 0.9%, P < 0.001). PVC burden of 16% by ROC curve analysis best separated the patients with TICMP compared to patients with preserved LVEF (sensitivity 100%, specificity 87%, area under curve 0.96). Conclusions: TICMP was relatively common (similar to 1 in every 15 patients) in our study population. The predictors of TICMP were male gender, absence of symptoms, PVC burden of >= 16%, persistence of PVCs throughout the day, and the presence of repetitive monomorphic VT. (J Cardiovasc Electrophysiol, Vol. 22, pp. 663-668, June 2011)en_US
dc.identifier.doi10.1111/j.1540-8167.2010.01986.xen_US
dc.identifier.endpage668en_US
dc.identifier.issn1045-3873
dc.identifier.issn1540-8167
dc.identifier.issue6en_US
dc.identifier.pmid21235667en_US
dc.identifier.startpage663en_US
dc.identifier.urihttps://doi.org/10.1111/j.1540-8167.2010.01986.x
dc.identifier.urihttps://hdl.handle.net/11454/44418
dc.identifier.volume22en_US
dc.identifier.wosWOS:000292422100007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cardiovascular Electrophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectleft ventricular outflow tracten_US
dc.subjectpremature ventricular complexesen_US
dc.subjectright ventricular outflow tracten_US
dc.subjecttachycardia-induced cardiomyopathyen_US
dc.subjectventricular tachycardiaen_US
dc.titleTachycardia-Induced Cardiomyopathy in Patients With Idiopathic Ventricular Arrhythmias: The Incidence, Clinical and Electrophysiologic Characteristics, and the Predictorsen_US
dc.typeArticleen_US

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