Evaluation of viral etiology in central nervous system infections from a university hospital point of view in izmir based on seven years data [Santral Sinir Sistemi Enfeksiyonlarinda Viral Etiyolojinin izmir'de Bir Üniversite Hastanesinin Yedi Yillik Verileri Üzerinden Degerlendirilmesi]

Basit Öğe Kaydı
dc.contributor.authorZeytinoglu A.
dc.contributor.authorErensoy S.
dc.contributor.authorSertoz R.
dc.contributor.authorAltuglu I.
dc.contributor.authorÇiçek C.
dc.contributor.authorKayin M.
dc.contributor.authorŞirin H.
dc.contributor.authorTaner S.
dc.date.accessioned2019-10-27T08:04:03Z
dc.date.available2019-10-27T08:04:03Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractThe serious diseases of the central nervous system (CNS); encephalitis and meningitis, have high mortality and morbidity rate especially not diagnosed and treated in time. Nucleic acid testing (NAT) is the tool of choice for viral diagnosis in CNS infections. In this study, viral etiological agents found in cerebrospinal fluid (CSF) samples sent to our university hospital virology laboratory for laboratory diagnosis of CNS infections were retrospectively evaluated and results were compared with other reports from our country. Viral etiological agents found in cerebrospinal fluid (CSF) samples sent to Ege University Faculty of Medicine Department of Medical Microbiology Virology Laboratories for laboratory diagnosis of CNS infection between 01.01.2009-31.12.2015 were evaluated retrospectively. A total of 3778 CSF tests were performed for cell culture of enterovirus (EV) in 487 samples and 3291 tests for nucleic acid testing (NAT) by real time polymerase chain reaction (PCR) in herpes simplex virus 1 (HSV1), herpes simplex virus 2 (HSV2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpes virus 6 (HHV6) and EV. VZV and EV NAPs were performed during the last one and five years period, respectively. NAT positive results for HSV1, HSV2, CMV, EBV, VZV, HHV6 and EV were 1.80% (24/1333), 0.08% (1/1333), 3.28% (19/580), 4.35% (22/506), 0.46% (1/216), 1.05% (5/478) and 3.37% (6/178), respectively. EV was isolated in 30 (6.20%) of 487 CSF samples by viral culture. Positive samples were mainly from pediatric, neurology and infectious diseases clinics as expected. The number of higher positive results were found in samples sentin December (35.3%), July (12.9%) and November (10.6%). Overall 80% of positive samples belonged to patients over 18 years old. When the results of other studies reported from Turkey are examined, although the positivity rates are generally similar, it is seen that the rates specific to certain factors are higher in selected smaller patient groups like HSV1 and EV. Rapid nucleic acid tests like multiplex PCR and microarray will provide more practical and effective laboratory diagnosis approach in CNS infections, since many more microorganisms may be causative agents.en_US
dc.identifier.doi10.5578/mb.53825en_US
dc.identifier.endpage135en_US
dc.identifier.issn0374-9096
dc.identifier.issue2en_US
dc.identifier.pmid28566076en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.5578/mb.53825
dc.identifier.urihttps://hdl.handle.net/11454/25455
dc.identifier.volume51en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherAnkara Microbiology Societyen_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCentral nervous system viral infectionsen_US
dc.subjectViral nucleic acid testsen_US
dc.titleEvaluation of viral etiology in central nervous system infections from a university hospital point of view in izmir based on seven years data [Santral Sinir Sistemi Enfeksiyonlarinda Viral Etiyolojinin izmir'de Bir Üniversite Hastanesinin Yedi Yillik Verileri Üzerinden Degerlendirilmesi]en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu