Intrathecal morphine reduces postoperative tramadol consumption in patients undergoing radical retropubic prostatectomy: a randomized trial

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dc.contributor.authorDeniz, M. Nuri
dc.contributor.authorErhan, E.
dc.contributor.authorUgur, G.
dc.date.accessioned2019-10-27T21:41:25Z
dc.date.available2019-10-27T21:41:25Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractBACKGROUND: Intrathecal (IT) morphine provides prolonged analgesia after major surgery. AIM: The aim of our study was to assess the impact of intrathecal morphine 200 mu g on patient-controlled analgesia (PCA) tramadol consumptions and postoperative pain in patients who underwent radical retropubic prostatectomy (RRP) under general anesthesia. MATERIALS AND METHODS: In this prospective trial, 56 men who underwent radical retropubic prostatectomy (RRP) were randomized into 2 groups. Group M received intrathecal morphine (200 mu g) before the induction of general anesthesia. Group C did not receive intrathecal morphine. Postoperative analgesia was provided with tramadol PCA. Pain scores, tramadol consumption, adverse effects, rescue analgesia were recorded. RESULTS: Total tramadol consumption at 24 hours and pain scores during 12 hours postoperatively were significantly lower in Group M compared with Group C (p < 0.05). Rescue analgesia and postoperative nausea were lower in Group M than in Group C (p < 0.05). CONCLUSIONS: Intrathecal morphine 200 mu g provided a significant reduction in tramadol consumption, postoperative pain scores, rescue analgesia, and postoperative nausea after RRP without serious adverse effects.en_US
dc.identifier.endpage838en_US
dc.identifier.issn1128-3602
dc.identifier.issue6en_US
dc.identifier.pmid23609368en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage834en_US
dc.identifier.urihttps://hdl.handle.net/11454/46652
dc.identifier.volume17en_US
dc.identifier.wosWOS:000325207900016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadical retropubic prostatectomyen_US
dc.subjectIntrathecal morphineen_US
dc.subjectPostoperative analgesia and tramadolen_US
dc.titleIntrathecal morphine reduces postoperative tramadol consumption in patients undergoing radical retropubic prostatectomy: a randomized trialen_US
dc.typeArticleen_US

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