Incidence and risk factors for hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation: A retrospective multicenter study of Turkish hematology research and education group (ThREG)

Basit Öğe Kaydı
dc.contributor.authorSoyer, Nur
dc.contributor.authorGunduz, Mehmet
dc.contributor.authorTekgunduz, Emre
dc.contributor.authorDeveci, Burak
dc.contributor.authorOzdogu, Hakan
dc.contributor.authorSahin, Handan Haydaroglu
dc.contributor.authorTopcuoglu, Pervin
dc.date.accessioned2021-05-03T20:37:07Z
dc.date.available2021-05-03T20:37:07Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractHepatic sinusoidal obstruction syndrome (HSOS) is a potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively evaluated the incidence, risk factors, treatment and survival for HSOS after allo-HSCT in Turkey. We also reported our experience of defibrotide (DF) for HSOS prophylaxis in high-risk (HR) patients. Across Turkey, 1153 patients from 10 centers were enrolled in the study. We evaluated the medical records of patients who were treated with allo-SCT between January 2012 and December 2015. The study included 1153 patients (687 males/466 females) with median age of 38 (15 - 71) years. The incidence of HSOS was 7.5 % (n = 86). The incidences of HSOS in the HR/DF +, HR/DF- and standard risk (SR) group were 8%, 66.7 % and 6.2 %, respectively. The rate of HSOS development was not statistically different between HR/DF + and SR group (p = 0.237). HSOS prophylaxis (defibrotide) was significantly decreased HSOS-related mortality (p = 0.004). The incidence of HSOS was found similar to literature in this large Turkish cohort. Defibrotide prophylaxis appears to be associated with low incidence of HSOS development and reduced HSOS-related mortality. Although these results are promising, future studies are needed to support the efficacy of defibrotide prophylaxis in patients with risk of HSOS.en_US
dc.identifier.doi10.1016/j.transci.2020.102827en_US
dc.identifier.issn1473-0502
dc.identifier.issue4en_US
dc.identifier.pmid32522474en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2020.102827
dc.identifier.urihttps://hdl.handle.net/11454/70352
dc.identifier.volume59en_US
dc.identifier.wosWOS:000564554400020en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSinusoidal obstruction syndromeen_US
dc.subjectProphylaxisen_US
dc.subjectDefibrotideen_US
dc.subjectHematopoietic stem cell transplantationen_US
dc.titleIncidence and risk factors for hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation: A retrospective multicenter study of Turkish hematology research and education group (ThREG)en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu