Idiopathic CD4+ T cell lymphocytopenia with the absence of B cells and CD8+28+ cells in peripheral blood

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dc.contributor.authorKutukculer N.
dc.contributor.authorAksu G.
dc.contributor.authorGenel F.
dc.contributor.authorOzturk C.
dc.date.accessioned2019-10-27T08:59:50Z
dc.date.available2019-10-27T08:59:50Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractThe absence of B cells and a severe decrease in CD8+28+ cells were observed in two female children with CD4+ T cell lymphocytopenia. Idiopathic (primary) CD4+ lymphocytopenia is a rare entity and its pathogenesis and genetics are not yet known. The literature was reviewed, in particular for severe alterations in B and CD8+28+ cells and for the role of NF-kappa B and p56lck in the immunopathogenesis. Whether the underlying mechanism in idiopathic CD4+ lymphocytopenia is found or not, these patients who present with severe symptoms of a combined immunodeficiency must be treated with intravenous immunoglobin regularly until they have a compatible donor for bone marrow transplantation.en_US
dc.identifier.doi10.1007/s102380200020en_US
dc.identifier.endpage146en_US
dc.identifier.issn1591-8890
dc.identifier.issue3en_US
dc.identifier.pmid12447612en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.1007/s102380200020
dc.identifier.urihttps://hdl.handle.net/11454/27922
dc.identifier.volume2en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofClinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone marrow transplantationen_US
dc.subjectIntravenous immunoglobulineen_US
dc.subjectPrimary (idiopathic) CD4+ lymphocytopeniaen_US
dc.titleIdiopathic CD4+ T cell lymphocytopenia with the absence of B cells and CD8+28+ cells in peripheral blooden_US
dc.typeArticleen_US

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