Importance of Source Control in the Subgroup of Intra-Abdominal Infections for Septic Shock Patients: Analysis of 390 Cases

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dc.authoridSipahi, Oguz Resat/0000-0002-1243-2746
dc.contributor.authorOnal, Ugur
dc.contributor.authorSeyhan, Deniz Akyol
dc.contributor.authorKetenoglu, Olcay Buse
dc.contributor.authorVahabi, Merve Mert
dc.contributor.authorElik, Dilsah Baskol
dc.contributor.authorMemetali, Seichan Chousein
dc.contributor.authorIsbilen, Gamze Sanlidag
dc.date.accessioned2024-08-31T07:50:20Z
dc.date.available2024-08-31T07:50:20Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: This study aimed to evaluate the epidemiology of septic shock (SS) associated with intraabdominal infections (IAI) as well as associated mortality and efficacy of early source control in a tertiary -care educational hospital. Methods: Patients who had SS with IAI and consulted by Infectious Diseases consultants between December 2013 and October 2022 during night shifts in our centre were analyzed retrospectively. Results: A total number of 390 patients were included. Overall, 30 -day mortality was 42.5% on day 3, while day 14 and 30 mortality rates were 63.3% and 71.3%, respectively. Source control by surgical or percutaneous operation was performed in 123 of 390 cases (31.5%), and the mortality rate was significantly lower in cases that were performed source control at any time during SS (65/123-52.8% vs 213/267-79.8%, p<0.001). In 44 of 123 cases (35.7%), source control was performed during the first 12 hours, and mortality was significantly lower in this group versus others (24/44-54.5% vs 254/346-73.4%, p=0.009). On the other hand, female gender (p<0.001, odds ratio(OR)= 2.943, 95%CI=1.714-5.054), diabetes mellitus (p= 0.014, OR=2.284, 95%CI=1.1794.424), carbapenem-resistant Gram-negative etiology (p=0.011, OR=4.386, 95%CI=1.398-13.759), SOFA >= 10 (p<0.001, OR=3.036, 95%CI=1.802 -5.114), lactate >3 mg/dl (p<0.001, OR=2.764, 95%CI=1.562-4.891) and lack of source control (p=0.001, OR=2.796, 95%CI=1.523-5.133) were significantly associated with 30 -day mortality in logistic regression analysis. Conclusion: Source control has a vital importance in terms of mortality rates for IAI-related septic shock patients. Our study underscores the need for additional research, as the present analysis indicates that early source control does not manifest as a protective factor in logistic regression.en_US
dc.identifier.doi10.4084/MJHID.2024.051
dc.identifier.issn2035-3006
dc.identifier.issue1en_US
dc.identifier.pmid38984090en_US
dc.identifier.scopus2-s2.0-85199398220en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.4084/MJHID.2024.051
dc.identifier.urihttps://hdl.handle.net/11454/105200
dc.identifier.volume16en_US
dc.identifier.wosWOS:001260583400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofMediterranean Journal of Hematology and Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectSeptic Shocken_US
dc.subjectIntra-Abdominal Infectionen_US
dc.subjectSource Control.en_US
dc.titleImportance of Source Control in the Subgroup of Intra-Abdominal Infections for Septic Shock Patients: Analysis of 390 Casesen_US
dc.typeArticleen_US

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