Association of macrophage migration inhibitory factor -173C allele polymorphism with steroid resistance in children with nephrotic syndrome

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dc.contributor.authorBerdeli A.
dc.contributor.authorMir S.
dc.contributor.authorOzkayin N.
dc.contributor.authorSerdaroglu E.
dc.contributor.authorTabel Y.
dc.contributor.authorCura A.
dc.date.accessioned2019-10-27T08:59:14Z
dc.date.available2019-10-27T08:59:14Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractThe potential effects of macrophage migration inhibitory factor (MIF) on the natural immune response are due to the inhibition of immune cell activation, which is regulated by glucocorticoids. In this study, we investigated MIF -173G/C genotype and C allele frequency in 214 patients with idiopathic nephrotic syndrome (INS) and 103 healthy volunteers. We found significant increases in GC genotype (OR=3, p=0.0009) and C allele frequency (OR=2.5, p=0.0007) in INS. Upon classifying patients as steroid responsive (n =137) or resistant (n =77), a 20-fold over-expression of the CC-genotype was found in the steroid-resistant group (OR=20, p=0.0002). Moreover, a significant increase in C allele frequency in patients with focal segmental glomerulosclerosis (FSGS) has also been noted when compared with other histopathological groups (OR=3.2, p=0.0017). Furthermore, significant increases in the CC genotype (15.6% vs 3.3%) and C allele (75% vs 32%) frequencies have been found in patients with permanent renal function failure (p =0.013 and p =0.0002, respectively). Patients with the CC genotype were found to be at considerably increased risk of permanent renal failure (OR=5.43, p=0.013) and end-stage renal disease (OR=5.53, p=0.020). Additionally, there was a correlation between age of detection of proteinuria and CC genotype. We found an earlier age of onset of proteinuria in patients with the CC genotype (1.9±1.7 years) than in patients who were GC-heterozygous (3.7±3.1 years) and GG-homozygous (3.6±2.9 years, p=0.88). In summary, our results indicate that the MIF-173 C allele confers an increased risk of susceptibility to INS and plays a crucial role in glucocorticoid responsiveness. © IPNA 2005.en_US
dc.identifier.doi10.1007/s00467-005-1930-9en_US
dc.identifier.endpage1571en_US
dc.identifier.issn0931-041X
dc.identifier.issue11en_US
dc.identifier.pmid16133063en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1566en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-005-1930-9
dc.identifier.urihttps://hdl.handle.net/11454/27731
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectFSGSen_US
dc.subjectGene polymorphismen_US
dc.subjectMIFen_US
dc.subjectNephrotic syndromeen_US
dc.subjectSRNSen_US
dc.titleAssociation of macrophage migration inhibitory factor -173C allele polymorphism with steroid resistance in children with nephrotic syndromeen_US
dc.typeArticleen_US

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