L-glutamic acid-g-poly hydroxyethyl methacrylate nanoparticles: acute and sub-acute toxicity and biodistribution potential in mice

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dc.authoridKarabay Yavasoglu, N.Ulku/0000-0002-7483-0184
dc.authorscopusid57201362301
dc.authorscopusid55318033800
dc.authorscopusid58655510500
dc.authorscopusid8955041400
dc.authorscopusid6603594798
dc.authorscopusid8633854100
dc.contributor.authorBakan, Buket
dc.contributor.authorOltulu, Fatih
dc.contributor.authorYıldırım, Yeliz
dc.contributor.authorYavaşoğlu, Altuğ
dc.contributor.authorAkgol, Sinan
dc.contributor.authorKarabay Yavaşoğlu, Nefise Ülkü
dc.date.accessioned2024-08-25T18:31:33Z
dc.date.available2024-08-25T18:31:33Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this safety study in mice was to determine in vivo toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 mg/kg body weight (bw). Multiple doses (25, 50, or 100 mg/kg bw) given over 28 days resulted in no significant differences in body and relative organ weights compared to control. These results are supported by biochemical and histological findings. Moreover, nanoparticle exposure did not result in statistically significant differences in micronucleus counts in bone marrow cells compared to control. Nanoparticle distribution was time-dependent, and they reached the organs and even bone marrow by hour 6, as established by ex vivo imaging with the IVIS (R) spectrum imaging system. In conclusion, L-glutamic acid-g-p(HEMA) polymeric nanoparticles appear biocompatible and have a potential use as a drug delivery system.en_US
dc.description.sponsorshipThe study was supported by the Ege University Scientific Research Foundation (project No. 2015/FEN/010). The authors would like to thank Professor Peter Hoet from the Catholic University in Leuven for his advice in drafting this manuscript. [2015/FEN/010]; Ege University Scientific Research Foundationen_US
dc.description.sponsorshipThe study was supported by the Ege University Scientific Research Foundation (project No. 2015/FEN/010). The authors would like to thank Professor Peter Hoet from the Catholic University in Leuven for his advice in drafting this manuscript.en_US
dc.identifier.doi10.2478/aiht-2023-74-3768
dc.identifier.endpage217en_US
dc.identifier.issn0004-1254
dc.identifier.issn1848-6312
dc.identifier.issue3en_US
dc.identifier.pmid37791671en_US
dc.identifier.scopus2-s2.0-85174539461en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://doi.org/10.2478/aiht-2023-74-3768
dc.identifier.urihttps://hdl.handle.net/11454/99942
dc.identifier.volume74en_US
dc.identifier.wosWOS:001080694100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofArhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectbiocompatibilityen_US
dc.subjectblood biochemistryen_US
dc.subjectgenotoxicityen_US
dc.subjecthistologyen_US
dc.subjectin vivo toxicityen_US
dc.subjectmicronucleus testen_US
dc.subjectpolymersen_US
dc.subjectDeliveryen_US
dc.subjectModelen_US
dc.titleL-glutamic acid-g-poly hydroxyethyl methacrylate nanoparticles: acute and sub-acute toxicity and biodistribution potential in miceen_US
dc.typeArticleen_US

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