Mesleksel asbest maruziyetinde bronkoalveoler lavaj sıvısındaki asbest cisimciği içeriğinin solunum fonksiyon testlerine etkisi
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada fren balatası üreten bir fabrikada çalışan işçilerde bronkoalveoler lavaj (BAL) sıvısındaki asbest cisimciği (AC) miktarının solunum fonksiyon testleri (SFT) üzerindeki etkisinin araştırılması amaçlanmıştır. Çalışmaya fabrika taraması sırasında SFT ve DLCO yapılan 288 işçiden DLCO <%80 olan 34 işçi alınarak, BAL sıvısında hücre analizi, asbest cisimciği ve asbest lifi incelemesi yapılmıştır. Yaş ortalaması 36.5 (±6.3) ve ortalama çalışma süresi 8.8 (±4.9) yıl olan 34 işçinin 14'ünde (%41.2) BAL sıvısında AC saptanmış ve ortalama AC/mL sayısı 2.5 (±6.3) bulunmuştur. BAL'da AC (+) olan grupta ortalama FEV1: %101.6 (±12.6), FVC: %102.2 (±11.2), FEV1/FVC: %100.5 (±8.5), Vmax50: %89.4 (±31.4), Vmax25: %67.8 (±28.3), DLCO: %53.9 (±15), DLCO/VA: %39.9 (±11.5); BAL'da ortalama alveoler makrofaj: %85.8 (±6.7), lenfosit: %6.3 (±3.9), PNL: %6.9 (±3.6), eozinofil: %1.5 (±1) bulunmuştur. BAL'da AC (-) olan grupta ise ortalama FEV1: %97.4 (±14), FVC: %96.9 (±11.1), FEV1/FVC: %101.3 (±7.9), Vmax50: %82.8 (±21.9), Vmax25: %68 (±26), DLCO: %60.3 (±8), DLCO/VA: %48.5 (±14.4); BAL'da ortalama alveoler makrofaj: %80.3 (±8.6), lenfosit: %8.7 (±8), PNL: %9 (±5.2), eozinofil: %1.6 (±1.1) olarak saptanmıştır. BAL'da AC saptanan 14 olgu ile saptanmayan 20 olgu karşılaştırıldığında FEV1, FVC, FEV1/FVC, Vmax50, Vmax25, DLCO, DLCO/VA ve BAL'ın hücresel dağılımı açısından gruplar arasında istatistiksel olarak anlamlı fark saptanmamış, ancak BAL'da AC saptanan grupta asbest lifi sayısı diğer gruptan anlamlı olarak yüksek bulunmuştur. Sonuç olarak, asbeste kısa süre maruz kalan olgularda BAL'daki AC miktarının SFT'ye etkisinin olmadığı, ancak BAL'da AC saptanmasının maruz kalmayı göstermede yararlı olabileceği düşünülmüştür.
In this study, we aimed to investigate the effect of asbestos body (AB) content in bronchoalveolar lavage (BAL) fluid on pulmonary function tests (PFT) among workers of a brake lining factory. Out of 288 workers that PFT and DLCO were performed during the investigation in the factory, 34 workers with DLCO <80% were enrolled. All the workers had PFT and DLCO measurements and cellular analysis, also AB and asbestos fibers in BAL fluid were evaluated. Mean age and mean number of years at work among 34 workers were 36.5 years (±6.3) and 8.8 years (±4.9), respectively. Fourteen (41.2%) of them had AB in their BAL fluid, and the mean number of AB per mL was 2.5 (±6.3). PFT and BAL results of the workers with AB positive in BAL were FEV1: 101.6% (±12.6), FVC: 102.2% (±11.2), FEVCO/FVC: 100.5% (±8.5), Vmax50: 89.4% (±31.4), Vmax25: 67.8% (±28.3), DLCO: 53.9% (±15), DLCO/VA: 39.9% (±11.5); mean percent of alveolar macrophages in BAL fluid were: 85.8% (±6.7), lymphocytes: 6.3% (±3.9), PNL: 6.9% (±3.6), and eosinophils: 1.5% (±1). PFT and BAL results of the workers with AB negative in BAL were FEV1: 97.4% (±14), FVC: 96.9% (±11.1), FEV1/FVC: 101.3% (±7.9), Vmax50: 82.8% (±21.9), Vmax25: 68% (±26), DLCO: 60.3% (±8), DLCO/VA: 48.5% (±14.4); mean percent of alveolar macrophages in BAL fluid were: 80.3% (±8.6), lymphocytes: 8.7% (±8), PNL: 9% (±5.2), and eosinophils: 1.6% (±1.1). When 14 subjects with asbestos bodies in BAL fluid were compared with 20 subjects without asbestos bodies, no significant difference was found in FEV1, FVC, FEV1/FVC, Vmax50, Vmax25, DLCO, DLCO/VA but the number of asbestos fibers was significantly higher in the group with asbestos bodies in BAL fluid. We concluded that in patients with short exposure duration, the number of asbestos bodies in BAL fluid did not have influence on PFT, but presence of asbestos bodies in BAL fluid could show exposure to asbestos.
In this study, we aimed to investigate the effect of asbestos body (AB) content in bronchoalveolar lavage (BAL) fluid on pulmonary function tests (PFT) among workers of a brake lining factory. Out of 288 workers that PFT and DLCO were performed during the investigation in the factory, 34 workers with DLCO <80% were enrolled. All the workers had PFT and DLCO measurements and cellular analysis, also AB and asbestos fibers in BAL fluid were evaluated. Mean age and mean number of years at work among 34 workers were 36.5 years (±6.3) and 8.8 years (±4.9), respectively. Fourteen (41.2%) of them had AB in their BAL fluid, and the mean number of AB per mL was 2.5 (±6.3). PFT and BAL results of the workers with AB positive in BAL were FEV1: 101.6% (±12.6), FVC: 102.2% (±11.2), FEVCO/FVC: 100.5% (±8.5), Vmax50: 89.4% (±31.4), Vmax25: 67.8% (±28.3), DLCO: 53.9% (±15), DLCO/VA: 39.9% (±11.5); mean percent of alveolar macrophages in BAL fluid were: 85.8% (±6.7), lymphocytes: 6.3% (±3.9), PNL: 6.9% (±3.6), and eosinophils: 1.5% (±1). PFT and BAL results of the workers with AB negative in BAL were FEV1: 97.4% (±14), FVC: 96.9% (±11.1), FEV1/FVC: 101.3% (±7.9), Vmax50: 82.8% (±21.9), Vmax25: 68% (±26), DLCO: 60.3% (±8), DLCO/VA: 48.5% (±14.4); mean percent of alveolar macrophages in BAL fluid were: 80.3% (±8.6), lymphocytes: 8.7% (±8), PNL: 9% (±5.2), and eosinophils: 1.6% (±1.1). When 14 subjects with asbestos bodies in BAL fluid were compared with 20 subjects without asbestos bodies, no significant difference was found in FEV1, FVC, FEV1/FVC, Vmax50, Vmax25, DLCO, DLCO/VA but the number of asbestos fibers was significantly higher in the group with asbestos bodies in BAL fluid. We concluded that in patients with short exposure duration, the number of asbestos bodies in BAL fluid did not have influence on PFT, but presence of asbestos bodies in BAL fluid could show exposure to asbestos.
Açıklama
Anahtar Kelimeler
Kulak, Burun, Boğaz
Kaynak
Türk Toraks Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
4
Sayı
2
