Association Between Hepatitis B and Hepatocellular Carcinoma Recurrence in Patients Undergoing Liver Transplantation

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dc.contributor.authorKiyici M.
dc.contributor.authorYilmaz M.
dc.contributor.authorAkyildiz M.
dc.contributor.authorArikan C.
dc.contributor.authorAydin U.
dc.contributor.authorSigirli D.
dc.contributor.authorNart D.
dc.contributor.authorYilmaz F.
dc.contributor.authorOzacar T.
dc.contributor.authorKarasu Z.
dc.contributor.authorKilic M.
dc.date.accessioned2019-10-26T23:57:26Z
dc.date.available2019-10-26T23:57:26Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/Aims: Hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) recurrences affect both patient and graft survivals post-orthotopic liver transplantation (OLT) in HBV patients with HCC. We analyzed the relationship between HBV and HCC recurrence in a large cohort of HBV-OLT patients with versus without HCC. Methods: Two hundred eighty-seven HBV patients with OLT (72 also with HCC) were included in the study. Mean follow-up in the post-OLT period was 31.7 ± 24.7 (range, 3-119) months. Results: Post-OLT HBV recurrence observed in 10.1% of patients was more prevalent among the HCC group; 23.6% versus 5.5% in patients with and without HCC, respectively. The mean interval for the development of HBV recurrence was 39.5 ± 28.5 (range, 2-99) months. Among 72 HCC patients, 8 patients (11.1%) had recurrent HCC, and 7 of them also had HBV recurrence. The mean interval for the development of HCC recurrence was 11.2 ± 7.85 (range, 2-23) months after OLT. OLT patients with HCC with tumors exceeding the Milan criteria had worse 1-, 3-, and 5-year survival rates than patients with HCC meeting the Milan criteria. HBV and HCC recurrence-free survivals were significantly lower in patients with HCC and HBV recurrence, respectively. In the 7 patients with both HCC and HBV recurrence, mean HBV recurrence time was 9.42 ± 6.75 months and mean HCC recurrence time was 9.57 ± 6.75 months. There was a strong correlation between HBV and HCC recurrence times. Cox proportional hazards regression analysis showed that only HCC recurrence was a significant independent predictor of HBV recurrence (P < .001; hazard ratio [HR] = 26.94; 95% confidence interval [CI] = 10.81-67.11). On the other hand, HBV recurrence (P = .013; HR = 5.80; 95% CI = 1.45-23.17) and nodule count (P = .014; HR = 13.08; 95% CI = 1.70-100.83) were significant predictors of HCC recurrence. Conclusions: HBV and HCC recurrences demonstrate a close relationship in patients with OLT. © 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.transproceed.2008.03.156en_US
dc.identifier.endpage1517en_US
dc.identifier.issn0041-1345
dc.identifier.issue5en_US
dc.identifier.pmid18589140en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1511en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2008.03.156
dc.identifier.urihttps://hdl.handle.net/11454/21016
dc.identifier.volume40en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAssociation Between Hepatitis B and Hepatocellular Carcinoma Recurrence in Patients Undergoing Liver Transplantationen_US
dc.typeArticleen_US

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