The Protective Effect of Aprotinin and ?-Tocopherol on Ischemia-Reperfusion Injury of the Rat Liver

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dc.contributor.authorPolat K.Y.
dc.contributor.authorAydinli B.
dc.contributor.authorPolat O.
dc.contributor.authorAydin U.
dc.contributor.authorYazici P.
dc.contributor.authorOzturk G.
dc.contributor.authorGundogdu C.
dc.contributor.authorKiziltunc A.
dc.date.accessioned2019-10-27T08:36:57Z
dc.date.available2019-10-27T08:36:57Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Liver injury caused by ischemia-reperfusion (I/R) processes is a complication of hepatic resection surgery and transplantation, particularly using grafts from marginal donors. Despite improvements in organ preservation and advances in surgical techniques, I/R injury remains a significant clinical problem. In this study, we investigated whether aprotinin provided protection against the adverse effects of I/R injury in liver tissue. Methods: Forty rats were randomized into four groups (n = 10): group I: (control group) I/R + no medication; group II: sham-operated group + no medication or I/R; group III: I/R + aprotinin; group IV: I/R + ?-tocopherol. Malondialdehyde (MDA) was measured in the liver tissue and superoxide dismutase (SOD), catalase (CAT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), as well as lactate dehydrogenase (LDH) in rat serum. Results: Administration of aprotinin and ?-tocopherol before I/R resulted in significant reductions of MDA levels compared to the I/R alone group (group I; P = .01 and P < .01, respectively). Administration of aprotinin or ?-tocopherol prior to I/R resulted in significant increases in SOD and CAT levels compared with the I/R group (P < .05 each). Compared to the I/R group, significant decreases in plasma AST, ALT, and LDH levels were observed both in the aprotinin and in the ?-tocopherol group (P < .05). Histological evaluation revealed the injury grade to be relatively lower among groups III and IV compared to group I. Discussion: In conclusion, rat hepatic structures in aprotinin and ?-tocopherol administered groups were well protected. Therefore, aprotinin may provide protection against the adverse effects of I/R injury in liver transplantation. © 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.transproceed.2007.11.047en_US
dc.identifier.endpage68en_US
dc.identifier.issn0041-1345
dc.identifier.issue1en_US
dc.identifier.pmid18261548en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2007.11.047
dc.identifier.urihttps://hdl.handle.net/11454/27462
dc.identifier.volume40en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe Protective Effect of Aprotinin and ?-Tocopherol on Ischemia-Reperfusion Injury of the Rat Liveren_US
dc.typeArticleen_US

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