Vitamin D Status of Exclusively Breastfed 4-Month-Old Infants Supplemented During Different Seasons

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dc.contributor.authorHalicioglu, Oya
dc.contributor.authorSutcuoglu, Sumer
dc.contributor.authorKoc, Feyza
dc.contributor.authorYildiz, Omur
dc.contributor.authorAkman, Sezin A.
dc.contributor.authorAksit, Sadik
dc.date.accessioned2019-10-27T21:41:06Z
dc.date.available2019-10-27T21:41:06Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: To examine the vitamin D status of 4-month-old exclusively breastfed infants supplemented with 400 IU daily of vitamin D and to determine whether there was any seasonal variation in serum 25-hydroxyvitamin D (25(OH)D) levels of infants. METHODS: In this cross-sectional study, serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, and 25(OH)D levels of 143 exclusively breastfed 4-month-old infants supplemented daily with 400 IU of vitamin D were measured in a temperate latitude, Izmir, Turkey, between May 2008 and April 2009. A questionnaire on demographic characteristics of infants and mothers, vitamin D supplementation of infants after birth, mothers' multivitamin supplementation, dressing habits, and consumption of dairy products during pregnancy was used. RESULTS: Vitamin D deficiency (<= 50 nmol/L) and insufficiency (51-74 nmol/L) were determined in 40 (28%) and 55 (38.5%) infants, respectively. During winter days, serum 25(OH) D levels were <20 ng/mL in 45.4% of infants and,10 ng/mL in 10.6% of infants. Season of blood sampling, compliance of vitamin D supplementation, maternal education level, and consumption of dairy products were highly predictive of serum 25(OH) D levels in multiple linear regression analysis (P < .05). The use of the Pearson correlation test found a statistically significant negative correlation between 25(OH) D and parathyroid hormone levels (r = -0.419, P < .001). CONCLUSIONS: Despite supplementation with 400 IU of vitamin D daily, the rate of vitamin D deficiency was worryingly high in 4-month-old exclusively breastfed infants living in Izmir, Turkey. So, additional studies are needed to clarify optimal amount of vitamin D supplementation to the infants, especially during winter days. Pediatrics 2012; 130: e921-e927en_US
dc.identifier.doi10.1542/peds.2012-0017en_US
dc.identifier.endpageE927en_US
dc.identifier.issn0031-4005
dc.identifier.issn1098-4275
dc.identifier.issue4en_US
dc.identifier.pmid23008460en_US
dc.identifier.startpageE921en_US
dc.identifier.urihttps://doi.org/10.1542/peds.2012-0017
dc.identifier.urihttps://hdl.handle.net/11454/46543
dc.identifier.volume130en_US
dc.identifier.wosWOS:000309412100018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Acad Pediatricsen_US
dc.relation.ispartofPediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbreastfeedingen_US
dc.subjectinfanten_US
dc.subjectseasonal variationen_US
dc.subjectvitamin Den_US
dc.titleVitamin D Status of Exclusively Breastfed 4-Month-Old Infants Supplemented During Different Seasonsen_US
dc.typeArticleen_US

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