Biological activities of skin and parotoid gland secretions of bufonid toads (Bufo bufo, Bufo verrucosissimus and Bufotes variabilis) from Turkey

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dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorKaris, Mert
dc.contributor.authorYalcin, Husniye Tansel
dc.contributor.authorGocmen, Bayram
dc.date.accessioned2019-10-27T23:10:11Z
dc.date.available2019-10-27T23:10:11Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractToad glandular secretions and skin extractions contain numerous natural agents which may provide unique resources for novel drug development. Especially the skin-parotoid gland secretions of toads from genus Bufo contain as many as 86 different types of active compounds, each with the potential of becoming a potent drug. In the present study, crude skin-parotoid gland secretions from Bufo bufo, Bufo verrucosissimus and Bufotes variabilis from Turkey were screened against various cancer cells together with normal cells using MTT assay. Furthermore, the antimicrobial properties of skin secretions were tested on selected bacterial and fungal species for assessing the possible medical applications. Antimicrobial activity of skin secretions was studied by determining minimal inhibitory concentration ( MIC) in broth dilution method. Hemolytic activity of each skin-secretion was also estimated for evaluating pharmaceutical potential. Both skin-parotoid gland secretions showed high cytotoxic effect on all cancerous and non-cancerous cell lines with IC50 values varying between <0.1 mu g/ml and 6.02 mu g/ml. MIC results of antimicrobial activity tests were found to be between 3.9 mu g/ml and 250 mu g/ml. No hemolytic activities on rabbit red blood cells at concentrations between 0.5 mu g/ml and 50 mu g/ml were observed. In conclusion, skin-parotoid secretions of bufonid toads might be remarkable candidates for anti-cancer and antimicrobial agents without hemolytic activities. (C) 2016 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z599]; Ege University Scientific Research Project CommissionEge University [15-FEN-004]; Ege University Science and Technology Centre (EBILTEM)Ege University [15-BIL-006]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technical Research Council of Turkey (TUBITAK) under Grant 114Z599, Ege University Scientific Research Project Commission (Project No: 15-FEN-004) and Ege University Science and Technology Centre (EBILTEM) under Grant 15-BIL-006. We also thank Mehmet Kosem for editing the manuscript.en_US
dc.identifier.doi10.1016/j.biopha.2016.03.034en_US
dc.identifier.endpage303en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid27133069en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage298en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2016.03.034
dc.identifier.urihttps://hdl.handle.net/11454/52841
dc.identifier.volume80en_US
dc.identifier.wosWOS:000375135100037en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmphibian skin secretionen_US
dc.subjectCytotoxicityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectHemolytic activityen_US
dc.titleBiological activities of skin and parotoid gland secretions of bufonid toads (Bufo bufo, Bufo verrucosissimus and Bufotes variabilis) from Turkeyen_US
dc.typeArticleen_US

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