Unusual course of an acute lymphoblastic leukemia case with i(9q) as a sole cytogenetic abnormality

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dc.contributor.authorCogulu, Ozgur
dc.contributor.authorKarapinar, Deniz Yimaz
dc.contributor.authorKaraca, Emin
dc.contributor.authorAydinok, Yesim
dc.contributor.authorÖzkınay, Ferda
dc.date.accessioned2019-10-27T19:40:39Z
dc.date.available2019-10-27T19:40:39Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractChromosomal changes are necessary in determining the classification, prognosis and using the appropriate therapeutic regimen in acute leukemia. Isochromosomes are uncommon chromosome aberations in childhood acute lymphoblastic leukemia (ALL) and the effect of i(9q) is not well established. We present an 8-year-old male case of pre-B ALL who has an unusual course at diagnosis. He was hospitalized three times in three different hospitals and blastic cells disappeared after the first hospitalization following blood transfusion without chemotherapy. In the following two hospitalizations no blastic cell was observed and transfused with a pack of erythrocyte suspension each time. In the fourth hospitalization, bone marrow aspiration revealed L1 type of lymphoid blast cell infiltration. The remission was achieved on the 15th day of the induction therapy and he has been in remission for the last 6 months. This unusual presentation and early remission achieved by induction therapy in this patient may support the literature that isochromosome 9q has a favourable outcome in childhood ALL. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.leukres.2006.02.018en_US
dc.identifier.endpage1463en_US
dc.identifier.issn0145-2126
dc.identifier.issue11en_US
dc.identifier.pmid16564090en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1461en_US
dc.identifier.urihttps://doi.org/10.1016/j.leukres.2006.02.018
dc.identifier.urihttps://hdl.handle.net/11454/40280
dc.identifier.volume30en_US
dc.identifier.wosWOS:000241346600021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLeukemia Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectisochromosome (9q)en_US
dc.subjectchildhooden_US
dc.subjectacute lymphoblastic leukemiaen_US
dc.titleUnusual course of an acute lymphoblastic leukemia case with i(9q) as a sole cytogenetic abnormalityen_US
dc.typeArticleen_US

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