Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells

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dc.contributor.authorCaglar, Hasan Onur
dc.contributor.authorBiray Avci, Cigir
dc.date.accessioned2020-12-01T12:02:24Z
dc.date.available2020-12-01T12:02:24Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractThe cell cycle is a complex and strictly controlled process, consisting of different phases. Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. the alterations of cell cycle genes can predispose normal cells to have a cancerous phenotype. Indeed, several mechanisms underlying the deregulation of the cell cycle have been identified in different types of cancer. Cancer stem cells (CSCs), a fraction of tumor cells, are selectively capable of initiating tumor development. However, the deregulation of the cell cycle progression in CSCs still remains incompletely understood. This review describes epigenetic alterations and aberrant transcriptional regulation of cell cycle genes in CSCs as well as cell cycle patterns of CSCs.en_US
dc.identifier.doi10.1007/s11033-020-05341-6en_US
dc.identifier.endpage3076en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue4en_US
dc.identifier.pmid32112300en_US
dc.identifier.scopus2-s2.0-85080996705en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3065en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-020-05341-6
dc.identifier.urihttps://hdl.handle.net/11454/62670
dc.identifier.volume47en_US
dc.identifier.wosWOS:000517415600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell cycleen_US
dc.subjectCyclinsen_US
dc.subjectCyclin-dependent kinasesen_US
dc.subjectCyclin-dependent kinase inhibitorsen_US
dc.subjectCanceren_US
dc.subjectBmi-1en_US
dc.subjectCancer stem cellsen_US
dc.titleAlterations of cell cycle genes in cancer: unmasking the role of cancer stem cellsen_US
dc.typeReview Articleen_US

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