The effects of calcium channel blockers are not related to their chemical structure in the collar model of the rabbit

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dc.contributor.authorYasa, M.
dc.contributor.authorKerry, Z.
dc.contributor.authorReel, B.
dc.contributor.authorAnacak, G. Yetik
dc.contributor.authorErtuna, E.
dc.contributor.authorOzer, A.
dc.date.accessioned2019-10-27T19:38:21Z
dc.date.available2019-10-27T19:38:21Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractPlacing a silicone collar around the rabbit carotid artery induces intimal thickening, an early stage in atherosclerosis and restenosis. We investigated whether treatment with oral pranidipine, a new potent, long lasting dihydropyridine calcium channel blocker (CCB), inhibited collar-induced intimal thickening in addition to the changes in vascular reactivity usually observed in this model. Pranidipine treatment did not inhibit collar-induced intimal thickening. Placing the collar around the carotid artery resulted in the characteristic changes in vascular reactivity, such as increased sensitivity to 5-hydroxytryptamine. Treatment with N-omega-nitro-L-arginine (100 mu M) and pranidipine, however, did not affect collarinduced changes in vascular reactivity. From results of this and previous studies, we conclude that pranidipine does not prevent collar-induced intimal thickening or collar-induced changes in vascular reactivity. Not all CCBs prevent collarinduced intimal thickening, suggesting that the effects of these agents are not related to their chemical structure and/or their calcium channel-blocking actions.en_US
dc.identifier.doi10.1177/147323000703500106en_US
dc.identifier.endpage71en_US
dc.identifier.issn0300-0605
dc.identifier.issue1en_US
dc.identifier.pmid17408056en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://doi.org/10.1177/147323000703500106
dc.identifier.urihttps://hdl.handle.net/11454/40074
dc.identifier.volume35en_US
dc.identifier.wosWOS:000245339300006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Med Publen_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpranidipineen_US
dc.subjectcalcium channel blockersen_US
dc.subjectatherosclerosisen_US
dc.subjectrabbit collar modelen_US
dc.subjectintimal thickeningen_US
dc.titleThe effects of calcium channel blockers are not related to their chemical structure in the collar model of the rabbiten_US
dc.typeArticleen_US

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