Cerebral strokes in children on intracorporeal ventricular assist devices: analysis of the EUROMACS Registry

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dc.contributor.authorSchweiger, Martin
dc.contributor.authorMiera, Oliver
dc.contributor.authorde By, Theo M. M. H.
dc.contributor.authorHubler, Michael
dc.contributor.authorBerger, Felix
dc.contributor.authorOzbaran, Mustafa
dc.contributor.authorLoforte, Antonio
dc.contributor.authorSeifert, Burkhardt
dc.contributor.authorGargiulo, Gaetano
dc.contributor.authorGummert, Jan
dc.contributor.authorMohacsi, Paul
dc.date.accessioned2019-10-27T10:42:17Z
dc.date.available2019-10-27T10:42:17Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractLittle is known about cerebral strokes in paediatric patients supported by intracorporeal continuous-flow ventricular assist devices. We retrospectively investigated patients younger than 19 years of age who were treated with an intracorporeal continuous-flow ventricular assist device in the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) database. The patients were stratified by body surface area in Group 1 [< 1.2 m(2) (n = 13)] and Group 2 [<1.2 m(2) (n = 38)]. Cerebral strokes, both ischaemic and haemorrhagic, were studied. Of the 2941 patients with ventricular assist device (VAD) implants listed in the database, 124 (4%) patients were less than 19 years of age. Fifty-one of them (2%) were supported with a continuous-flow ventricular assist device. Group 1 (6 female and 7 male) had a mean age (+/- SD) of 9 +/- 2.3 years compared with 15.6 +/- 1.8 years in Group 2 (21 female and 17 male). Three (23%) patients died in Group 1 on VAD support, whereas 5 (13%) patients died in Group 2 (P = 0.21; log-rank test). Seven (54%) patients with a VAD in Group 1 and 17 (45%) patients in Group 2 underwent transplantation (P = 0.29); of these, 1 (8%) patient recovered (Group 1) with subsequent device explantation. The other patients, 2 in Group 1 and 16 in Group 2, were still on device support at the time of the analysis. There were no cerebral strokes in Group 1, but 4 cerebral strokes (11% of Group 2, 8% of a total of 51 patients in Groups 1 and 2 combined) occurred in Group 2 (3 patients died; P = 0.26; log-rank test). Taken together, the incidence of cerebral strokes in this paediatric cohort of patients with an intracorporeal VAD was 0.1 per patient-year. The incidence of cerebral strokes in children with intracorporeal VADs (0.1 per patient-year) seems to be low irrespective of the body surface area.en_US
dc.identifier.doi10.1093/ejcts/ezx342en_US
dc.identifier.endpage421en_US
dc.identifier.issn1010-7940
dc.identifier.issn1873-734X
dc.identifier.issue2en_US
dc.identifier.pmid29029180en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage416en_US
dc.identifier.urihttps://doi.org/10.1093/ejcts/ezx342
dc.identifier.urihttps://hdl.handle.net/11454/30677
dc.identifier.volume53en_US
dc.identifier.wosWOS:000424256500018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofEuropean Journal of Cardio-Thoracic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectIntracorporeal VADen_US
dc.subjectStrokeen_US
dc.subjectNeurologic complicationsen_US
dc.titleCerebral strokes in children on intracorporeal ventricular assist devices: analysis of the EUROMACS Registryen_US
dc.typeArticleen_US

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