Evaluation of Ocular Surface and Meibomian Glands in Patients With Scleroderma

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dc.authoridPalamar, Melis/0000-0002-2494-0131
dc.authorscopusid57226519027
dc.authorscopusid23989747000
dc.authorscopusid14040875800
dc.authorscopusid6603074949
dc.authorscopusid7003943383
dc.authorwosidPalamar, Melis/H-5903-2013
dc.contributor.authorAdiguzel, Seyma
dc.contributor.authorPalamar, Melis
dc.contributor.authorYargucu, Figen
dc.contributor.authorOksel, Fahrettin
dc.contributor.authorYagci, Ayse
dc.date.accessioned2023-01-12T20:00:44Z
dc.date.available2023-01-12T20:00:44Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose: To evaluate the prevalence of dry eye and meibomian gland dysfunction in patients with scleroderma. Methods: A total of 32 patients with scleroderma (study group) and 31 healthy subjects (control group) were enrolled. Besides routine ophthalmologic evaluation, Schirmer 1 test, tear break-up time, tear osmolarity, ocular surface staining with fluorescein (Oxford score), and Ocular Surface Disease Index (OSDI) score, meibomian gland dysfunction evaluation (foamy tears, telangiectasia of the eyelid, eyelid contour abnormalities, and meibomian plugs), and meibography were performed. Results: Sixty-four eyes of 32 patients with scleroderma and 62 eyes of 31 healthy individuals were evaluated. Mean ages of the study group was 48.34 +/- 9.73 years (21-62 years) and of the control group was 45.84 +/- 4.42 years (38-54 years) (P = 0.067). Mean duration of systemic sclerosis or scleroderma in study group was 9.78 +/- 7.40 years (1-30 years). Mean tear break-up time was shorter in study group than that in the control group (P < 0.0005). No statistical differences were detected for osmolarity, OSDI score, and Schirmer 1 values between groups (P = 0.051, P = 0.053, and P = 0.358, respectively). The prevalence of grade 1 and higher Oxford score was higher in the study group (P < 0.0005). Upper meiboscores of grade 1 and higher were found to be more common in the study group than those in the control group (P = 0.036). The presence of foamy tears and telangiectasia of the eyelids were significantly higher in the study group (P = 0.002 and P = 0.002, respectively). OSDI score was the only significantly correlated data with disease duration (Spearman rho coefficient = 0.396, P = 0.001). Conclusions: Evaporative type dry eye is more common in patients with scleroderma than the healthy population.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination Unit [2017-TIP-041]en_US
dc.description.sponsorshipSupported by Ege University Scientific Research Projects Coordination Unit (Project Number: 2017-TIP-041).en_US
dc.identifier.doi10.1097/ICO.0000000000002551
dc.identifier.endpage981en_US
dc.identifier.issn0277-3740
dc.identifier.issn1536-4798
dc.identifier.issue8en_US
dc.identifier.pmid33079918en_US
dc.identifier.scopus2-s2.0-85111789737en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage977en_US
dc.identifier.urihttps://doi.org/10.1097/ICO.0000000000002551
dc.identifier.urihttps://hdl.handle.net/11454/77381
dc.identifier.volume40en_US
dc.identifier.wosWOS:000711685000007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCorneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcorneaen_US
dc.subjectdry eyeen_US
dc.subjectmeibomian gland dysfunctionen_US
dc.subjectmeibographyen_US
dc.subjectocular surfaceen_US
dc.subjectosmolarityen_US
dc.subjectsclerodermaen_US
dc.subjectDry-Eye Syndromeen_US
dc.subjectSystemic-Sclerosisen_US
dc.subjectPrevalenceen_US
dc.subjectManifestationsen_US
dc.subjectSymptomsen_US
dc.subjectTherapyen_US
dc.subjectDiseaseen_US
dc.subjectSignsen_US
dc.titleEvaluation of Ocular Surface and Meibomian Glands in Patients With Sclerodermaen_US
dc.typeArticleen_US

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