Central defect type partial ACL injury model on goat knees: The effect of infrapatellar fat pad excision

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dc.contributor.authorKarakilic B.
dc.contributor.authorTaskiran E.
dc.contributor.authorDoganavsargil B.
dc.contributor.authorUzun B.
dc.contributor.authorCelik S.
dc.contributor.authorKaya Bicer E.
dc.date.accessioned2019-10-26T21:21:30Z
dc.date.available2019-10-26T21:21:30Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The mid-substance central defect injury has been used to investigate the primary healing capacity of the anterior cruciate ligament (ACL) in a goat model. The sagittal plane stability on this model has not been confirmed, and possible effects of fat pad excision on healing have not been evaluated. We hypothesize that excising the fat pad tissue results in poorer ligament healing as assessed histologically and decreased tensile strength of the healing ligament. We further hypothesize that the creation of a central defect does not affect sagittal plane knee stability. Methods: A mid-substance central defect was created with a 4-mm arthroscopic punch in the ACLs of right knees of all the subjects through a medial mini-arthrotomy. Goats were assigned to groups based on whether the fat pad was preserved (group 1, n = 5) or excised completely (group 2, n = 5). The left knees served as controls in each goat. Histopathology of the defect area along with measurement of type I collagen in one goat from each group were performed at 10th week postoperatively. The remaining knees were evaluated biomechanically at the 12th week, by measuring anterior tibial translation (ATT) of the knee joints at 90° of flexion and testing tensile properties (ultimate tensile load (UTL), ultimate elongation (UE), stiffness (S), failure mode (FM)) of the femur-ACL-tibia complex. Results and discussion: Histopathology analysis revealed that the central defect area was fully filled macroscopically and microscopically. However, myxoid degeneration and fibrosis were observed in group 2 and increased collagen type I content was noted in group 2. There were no significant differences within and between groups in terms of ATT values (p = 0.715 and p = 0.149, respectively). There were no significance between or within groups in terms of ultimate tensile load and ultimate elongation; however, group 2 demonstrated greater stiffness than group 1 that was correlated with the fibrotic changes detected microscopically (p = 0.043). Conclusions: The central defect type injury model was confirmed to be biomechanically stable in a goat model. Resection of the fat pad was noted to negatively affect defect healing and increase ligament stiffness in the central defect injury model. © 2015 Karakilic et al.en_US
dc.identifier.doi10.1186/s13018-015-0281-xen_US
dc.identifier.issn1749-799X
dc.identifier.issue1en_US
dc.identifier.pmid26338041en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s13018-015-0281-x
dc.identifier.urihttps://hdl.handle.net/11454/16878
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofJournal of Orthopaedic Surgery and Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfrapatellar fat paden_US
dc.subjectPartial ACL injury modelen_US
dc.subjectPrimary healingen_US
dc.titleCentral defect type partial ACL injury model on goat knees: The effect of infrapatellar fat pad excisionen_US
dc.typeArticleen_US

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